Prevention of hepatitis B

Cold Spring Harbor Perspectives in Medicine
Mei-Hwei Chang, Ding-Shinn Chen

Abstract

Hepatitis B virus (HBV) causes life-threatening liver disease. It is transmitted through a horizontal route or a mother-to-infant route, and the latter is the major route in endemic areas. Prevention of HBV infection by immunization is the best way to eliminate HBV-related diseases. The HBV vaccine is the first human vaccine using a viral antigen from infected persons, which is safe and effective. Either passive immunization by hepatitis B immunoglobulin (HBIG) or active immunization by HBV vaccine is effective, and a combination of both yields the best efficacy in preventing HBV infection. The impact of universal HBV immunization is huge, with 90%-95% effectiveness in preventing chronic HBV infection. It is the first cancer preventive vaccine with a protective efficacy against hepatocellular carcinoma (HCC) of ∼ 70%. Nevertheless, further effort is still needed to avoid vaccine failure and to increase the global coverage rate.

Citations

Nov 15, 2015·Expert Review of Gastroenterology & Hepatology·Wan-Hsin WenMei-Hwei Chang
Jul 18, 2015·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Chih-Lin Lin, Jia-Horng Kao
Dec 15, 2015·Best Practice & Research. Clinical Gastroenterology·Jia-Horng Kao
Nov 21, 2017·The Journal of Infectious Diseases·Huey-Ling ChenMei-Hwei Chang
Jul 31, 2018·Sports Health·Christopher D Boston, Jennifer J Bryan
Apr 5, 2020·Journal of Gastroenterology and Hepatology·Tyng-Yuan JangMing-Lung Yu
Mar 19, 2019·Journal of Medical Virology·Xueyan WangZhong-Liao Fang
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Nov 2, 2020·Best Practice & Research. Clinical Obstetrics & Gynaecology·Tejasvi Chaudhari
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