PMID: 8946326Nov 6, 1996Paper

Prevention of high blood pressure by reducing sympathetic innervation in the spontaneously hypertensive rat

Journal of the Autonomic Nervous System
J A BrockR A Rush

Abstract

It has previously been reported that the increase in blood pressure in the spontaneously hypertensive rat (SHR) occurs concurrently with a marked increase in thickness of the arterial wall and an increase in vascular innervation, particularly for the small muscular arteries. The purpose of the present study was to determine whether prevention of the increase in vascular innervation could prevent elevation of blood pressure in the SHR. We found that intraperitoneal injection of a single dose of an antiserum to nerve growth factor (anti-NGF) into young SHRs (postnatal day 19-24) caused a marked reduction in mean blood pressure at age 3-4 months from the raised value of 24.2 +/- 0.5 kPa to 18.9 +/- 0.8 kPa. By comparison, treated Wistar Kyoto rats (WKYs) maintained normal blood pressures. The treatment reduced the amplitude of the intracellularly recorded excitatory junction potential and the NA content of mesenteric arteries in the SHR, leaving the values similar to those of control WKYs. The NA content of these vessels was also reduced in treated WKYs. Importantly, the thickness of the vessel wall, which was greater in the SHR than the WKY, was not significantly altered by anti-NGF treatment. It is concluded that anti-NGF treatm...Continue Reading

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Citations

Nov 29, 2001·Journal of Hypertension·S H Zhang, R A Rush
Aug 1, 1997·Clinical and Experimental Pharmacology & Physiology·R A RushX F Zhou
Jul 20, 2005·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Kiyomitsu NemotoTakashi Ueyama
Feb 1, 2014·Pflügers Archiv : European journal of physiology·Ivana Y-T KuoCaryl E Hill
Apr 24, 2015·Clinical and Experimental Pharmacology & Physiology·Maiko OharaHiroshi Inoue
Apr 11, 2001·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·E PerfilievaP S Eriksson
May 10, 2000·Blood Pressure·D T O'ConnorR J Parmer
Jul 13, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·D S MartinJ L Williams
Oct 3, 1999·Physiological Reviews·J Zicha, J Kunes

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