Prevention of HIV-1 infection and preservation of CD4 function by the binding of CPFs to gp120

Science
R W FinbergS J Burakoff

Abstract

Infection by human immunodeficiency virus type-1 (HIV-1) is initiated when its envelope protein, gp120, binds to its receptor, the cell surface glycoprotein CD4. Small molecules, termed N-carbomethoxycarbonyl-prolyl-phenylalanyl benzyl esters (CPFs), blocked this binding. CPFs interacted with gp120 and did not interfere with the binding of CD4 to class II major histocompatibility complex molecules. One CPF isomer, CPF(DD), preserved CD4-dependent T cell function while inhibiting HIV-1 infection of H9 tumor cells and human T cells. Although the production of viral proteins in infected T cells is unaltered by CPF(DD), this compound prevents the spread of infection in an in vitro model system.

References

Jul 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·D C DiamondS J Burakoff
Nov 28, 1986·Science·Q J SattentauP C Beverley
Aug 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·M BabaE De Clercq
Feb 9, 1989·Nature·D J CaponJ E Groopman
Mar 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·R J GurleyJ E Groopman
May 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·D ScholsE De Clercq
Jan 1, 1989·Annual Review of Immunology·B E BiererS J Burakoff
Sep 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·P L NaraL E Eiden
Jan 7, 1988·Nature·R A FisherR T Schooley
Jan 7, 1988·Nature·A TrauneckerK Karjalainen
Oct 1, 1968·Applied Microbiology·F A MillerI W McLean

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Citations

Aug 1, 1991·Current Opinion in Immunology·J S McDougalP J Maddon
Jan 4, 1997·Biochimica Et Biophysica Acta·Y WatanabeY Tominaga
Sep 1, 1994·Bioorganic & Medicinal Chemistry·S RamurthyM Kahn
Jan 31, 1991·The New England Journal of Medicine·W C Greene
Jul 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·S ChenM I Greene
Jan 1, 1995·AIDS Research and Human Retroviruses·S DemariaY Bushkin
Jan 24, 2002·The Journal of International Medical Research·T OhkuboS Sawada
Jul 26, 1996·The Journal of Biological Chemistry·F A RobeyP P Roller
Jan 1, 1991·Journal of Receptor Research·E J Ariëns
Jun 1, 1994·International Journal of Peptide and Protein Research·L VenkatramaniD Van der Helm
Apr 1, 1995·Clinical Microbiology Reviews·E De Clercq

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