PMID: 1208597Dec 1, 1975Paper

Prevention of hypertension in the SH rat: effects of differential central catecholamine depletion

Proceedings of the Society for Experimental Biology and Medicine
L ErinoffS Oparil

Abstract

Six-hydroxydopamine (6-OHDA) was administered intraventricularly to 6-week-old male spontaneously hypertensive (SH) rats of the Okomoto strain and to normotensive rats of the Kyoto-Wistar strain. In addition, bilateral lateral tegmental lesions were placed in 35-40-day-old SH rats to interrupt ascending noradrenergic pathways. SH rats treated with 6-OHDA did not develop hypertension and had lower heart rates than control rats. Blood pressure and heart rate of Kyoto-Wistar animals were unaffected by the drug treatment. 6-OHDA produced widespread depletion of norepinephrine throughout the CNS of both SH and Kyoto-Wistar rats. Bilateral lateral tegmental lesions interrupted the dorsal noradrenergic bundle and depleted forebrain norepinephrine. These lesions did not prevent the development of hypertension and led to an increased heart rate. It is concluded that 6-OHDA does not produce its effect through a nonspecific lowering of blood pressure, but rather, that it interferes with the expression of the hypertensive syndrome. The lack of effect seen following depletion of forebrain norepinephrine as the result of interruption of the dorsal noradrenergic bundle indicates that the fibers destroyed by this lesion are not essential for t...Continue Reading

Citations

Feb 1, 1992·Brain Research Bulletin·M Van den BuuseJ Wagner
Jun 1, 1986·Clinical and Experimental Pharmacology & Physiology·M van den BuuseW de Jong
Jan 1, 1983·Clinical and Experimental Hypertension. Part A, Theory and Practice·L G HowesW J Louis
Jan 1, 1989·Clinical and Experimental Hypertension. Part A, Theory and Practice·J M MeyerJ A Weyhenmeyer
Mar 11, 2008·Experimental Physiology·S Kasparov, A G Teschemacher
Dec 1, 1983·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·M KadekaroL Sokoloff
Nov 1, 1984·Hypertension·M van den BuuseW de Jong
Aug 6, 2003·Hypertension·Monica Akemi SatoEduardo Colombari
Mar 1, 1981·Circulation Research·N C Trippodo, E D Frohlich
Sep 1, 1984·Journal of Autonomic Pharmacology·L G Howes
Oct 3, 2001·Physiological Reviews·H E de Wardener

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