Prevention of inflammation-mediated acquisition of metastatic properties of benign mouse fibrosarcoma cells by administration of an orally available superoxide dismutase

British Journal of Cancer
F OkadaM Hosokawa

Abstract

Weakly tumorigenic and nonmetastatic QR-32 cells derived from a fibrosarcoma in C57BL6 mouse are converted to malignant cells once they have grown after being coimplanted with a gelatine sponge which induces inflammation. We administered a newly developed peroral superoxide dismutase (SOD), oxykine, and as control vehicle, gliadin and saline, starting 2 days before the coimplantation and continued daily throughout the experiment. In the oxykine group, tumour incidence was lower (41%) than in the gliadin or saline group (83 and 79%, respectively). The inhibitory effect of oxykine was lost when an individual component of oxykine was administered, that is, SOD alone and gliadin alone. The effect was also abolished when administered by intraperitoneal route. When perfused in situ with nitroblue tetrazolium, an indicator of superoxide formation, the tumour masses from gliadin and saline groups displayed intense formazan deposition, whereas, those from oxykine group had less deposition. Enzymatic activity of SOD was also increased in oxykine group. Arising tumour cells in gliadin and saline groups acquired metastatic phenotype, but those in oxykine group showed reduced metastatic ability. These results suggested that the orally activ...Continue Reading

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Citations

Jun 13, 2012·World Journal of Gastroenterology : WJG·Mohd Aminudin MustaphaRavindran Ankathil
Apr 20, 2017·International Journal of Molecular Sciences·Yusuke KandaFutoshi Okada
Oct 10, 2009·The American Journal of Pathology·Kunishige OnumaFutoshi Okada
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Dec 8, 2006·The Biochemical Journal·Barry Halliwell
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Apr 28, 2021·Critical Reviews in Food Science and Nutrition·Mohammad Nazmul IslamMohammad S Mubarak
Mar 29, 2008·Cancer Letters·Rodrigo FrancoMihalis I Panayiotidis

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Methods Mentioned

BETA
transfection
flow cytometry
X-ray

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