PMID: 6112178Jan 1, 1981Paper
Prevention of insulin aggregation by dicarboxylic amino acids during prolonged infusion
Diabetes
J BringerG M Grodsky
Abstract
The dicarboxylic amino acids, aspartic and glutamic acid, at their isoelectric pH, reduced aggregation of insulin solutions in vitro for 16 days during continuous agitation at 37 degrees C. Unprotected insulin solutions, when infused via a 14-day implantable infusion device in diabetic Chinese hamsters, controlled plasma glucose levels for only 2 days, followed by escape coincident with insulin aggregation. However, when insulin solutions were protected with glutamic acid, euglycemia was maintained for the 14-day life of the device.
Citations
Sep 1, 1983·Diabetologia·J Mirouze
Jul 1, 1985·Diabetologia·U Grau
Jun 1, 1982·Diabetologia·M B Davidson
Mar 15, 2011·Pharmaceutical Research·Sébastien DasnoyVéronique Préat
Apr 26, 2005·Journal of Colloid and Interface Science·S H MollmannU Elofsson
Nov 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·V SluzkyR Langer
Jan 1, 1987·Journal of Clinical Pathology·E K Gini, J Sonnet
Aug 1, 1985·The Journal of Clinical Investigation·L J WardzalaE S Horton
Mar 1, 1987·The Journal of Clinical Investigation·B B KahnS W Cushman
Feb 13, 1992·Biochimica Et Biophysica Acta·P D Jeffrey, G B Treacy
Feb 18, 2005·Journal of Hypertension·Adil El Midaoui, Jacques de Champlain
Jan 1, 1993·Journal of Drug Targeting·A K Banga, R Mitra
Mar 1, 1983·Journal of Pharmaceutical Sciences·S SatoS W Kim
Dec 1, 1983·Journal of Pharmaceutical Sciences·R Quinn, J D Andrade
Jun 1, 1995·Kidney International·A JaraA J Felsenfeld
Apr 1, 1982·IEEE Transactions on Bio-medical Engineering·A M Albisser, W J Spencer
Feb 1, 1987·The Journal of Pathology·T M MayhewK N McCallum
Dec 1, 1988·Journal of Neurochemistry·M ManinJ Grizard
Jan 1, 1993·Brain Research Bulletin·P A IsraelD P Figlewicz
Apr 1, 1983·Metabolism: Clinical and Experimental·D G Patel
Sep 1, 1983·American Journal of Hematology·R M NalbandianW H Hoffman
Assessment of a new insulin preparation for implanted pumps used in the treatment of type 1 diabetes
Apr 17, 2014·Diabetes Technology & Therapeutics·Pauline SchaepelynckNathalie Jeandidier
Nov 1, 1986·Diabetic Medicine : a Journal of the British Diabetic Association·J BrangeC Kühl
Dec 2, 1999·Cell Transplantation·W E Fisher
Nov 1, 1990·The American Journal of Physiology·D A PelligrinoR F Albrecht
Nov 7, 2008·Bioconjugate Chemistry·Marsiyana M HenricusIpsita A Banerjee
Feb 13, 1989·Brain Research·D A PelligrinoR F Albrecht
❮ Previous
Next ❯
Related Concepts
Related Feeds
American Diabetes Association Journals
Discover the latest diabetes research published by the journals from the American Diabetes Association.
Related Papers
Acta diabetologica latina
J MirouzeD Chenon
Medical Hypotheses
R M NalbandianF H Reeser