PMID: 3756318Sep 1, 1986Paper

Prevention of intravascular blood coagulation in rats by DIP-alpha-thrombin administration

Biulleten' eksperimental'noĭ biologii i meditsiny
S M StrukovaB A Kudriashov

Abstract

The possibility of prevention of intravascular blood coagulation in rats by DIP-alpha-thrombin devoid of proteolytic activity and capable of stimulating the reaction of anticoagulation system was studied. The injection of lethal thromboplastin dose was shown to produce a sharp increase in soluble fibrin blood content, total disappearance of fibrinolytic activity and intravascular blood coagulation. The animals died of thrombosis in 90% of cases. It was established that the injection of lethal thromboplastin dose 5 min after DIP-alpha-thrombin injection caused a 13% lethality from thrombosis. No reliable changes in fibrinolytic activity and soluble fibrin content were observed. A significant increase in thrombin and recalcification time was recorded. It is suggested that DIP-alpha-thrombin prevents intravascular blood coagulation induced by lethal thromboplastin dose due to mobilization of the reserve capacities of neuro-humoral anticoagulation system.

References

Oct 15, 1984·Thrombosis Research·F B TaylorB K Beller
Jan 1, 1981·Annals of the New York Academy of Sciences·J W Fenton

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Citations

Mar 1, 1967·Biulleten' eksperimental'noĭ biologii i meditsiny·L G VoronianskaiaB I Kuznik
Dec 1, 1965·Biulleten' eksperimental'noĭ biologii i meditsiny·B A KudriashovV A Sazhnikov
Sep 1, 1971·Biulleten' eksperimental'noĭ biologii i meditsiny·V P BaludaA G Aladatov
Aug 1, 1974·Biulleten' eksperimental'noĭ biologii i meditsiny·L I Ul'ianovaA E Gosheva
Sep 1, 1981·Biulleten' eksperimental'noĭ biologii i meditsiny·D Ts BudazhapovaN N Tsybikov

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