PMID: 8964737Mar 1, 1996Paper

Prevention of ischemia-reperfusion lung injury by inhaled nitric oxide in neonatal piglets

Journal of Applied Physiology
F Barbotin-LarrieuP Herve

Abstract

Lung ischemia-reperfusion results in a decrease in the release of nitric oxide (NO) by the pulmonary endothelium. NO may have lung-protective effects by decreasing neutrophil accumulation in the lung. We tested whether NO inhalation would attenuate reperfusion-induced endothelial dysfunction and increases in microvascular permeability and total pulmonary vascular resistance (RT) by preventing neutrophil lung accumulation. After baseline determinations of RT, coefficient of filtration (Kfc), and circulating neutrophil counts, isolated neonatal piglet lungs were subjected to a 1-h period of ischemia followed by a 1-h period of blood reperfusion and reventilation with or without addition of NO (10 ppm). NO prevented reperfusion-induced increases in RT and Kfc, as well as the decrease in circulating neutrophils. After reperfusion, increases in Kfc were correlated with decreases in circulating neutrophils. NO prevented reperfusion-induced decrease in endothelium-dependent relaxation in precontracted pulmonary arterial rings. This demonstrates that inhaled NO prevents microvascular injury, endothelial dysfunction, and pulmonary neutrophil accumulation in a neonatal piglet model of lung ischemia-reperfusion.

Citations

Feb 2, 1999·American Journal of Respiratory and Critical Care Medicine·A SerrafC Planche
Aug 3, 1999·American Journal of Respiratory and Critical Care Medicine·K HondaT Tomita
Oct 3, 1999·Critical Care Medicine·L M Bigatello, W E Hurford
Jul 13, 2002·American Journal of Physiology. Lung Cellular and Molecular Physiology·Larissa A ShimodaDavid B Pearse
Apr 29, 2008·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·Stephen TrzeciakUNKNOWN Microcirculatory Alterations in Resuscitation and Shock (MARS) Investigators
Dec 17, 2008·Journal of Perinatology : Official Journal of the California Perinatal Association·A Bin-Nun, M D Schreiber
Jul 24, 2012·Transplant International : Official Journal of the European Society for Organ Transplantation·Akihiro OhsumiHiroshi Date
Aug 14, 2001·American Journal of Respiratory and Critical Care Medicine·H SchütteF Grimminger
Aug 26, 1999·American Journal of Respiratory Cell and Molecular Biology·H E Marshall, J S Stamler
Feb 5, 2009·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Lauren PhillipsLuis H Toledo-Pereyra
May 11, 2010·American Journal of Physiology. Lung Cellular and Molecular Physiology·Katerina VaporidiWarren M Zapol
Aug 25, 2000·American Journal of Physiology. Lung Cellular and Molecular Physiology·H SchütteF Grimminger
Mar 15, 2006·Kidney & Blood Pressure Research·Tienush RassafMalte Kelm
Feb 28, 2004·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Christopher L HubbleReese H Clark
Apr 15, 2004·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Niranjan Kissoon
Oct 6, 1999·American Journal of Respiratory and Critical Care Medicine·G HermleF Grimminger
Jun 25, 2005·American Journal of Respiratory and Critical Care Medicine·Richard D BlandAmy J MacRitchie
Oct 16, 1999·Anesthesiology·W SteudelW M Zapol
May 30, 2015·Nutrition Reviews·Catherine P BondonnoJonathan M Hodgson
Dec 22, 1999·The American Journal of Physiology·A Fox-RobichaudP Kubes
Oct 4, 2000·Physiological Reviews·V Hampl, J Herget
Jan 24, 2004·Circulation Research·Ella S M NgPaul Kubes
Jun 9, 2001·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·I TakeyoshiY Morishita
May 16, 2015·Critical Reviews in Food Science and Nutrition·Catherine P BondonnoJonathan M Hodgson
Jan 23, 2003·The Annals of Thoracic Surgery·Shinichi HatsuokaJohn E Mayer
Nov 14, 1997·Seminars in Perinatology·N N Finer, K J Barrington

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