PMID: 6129881Jan 1, 1983Paper

Prevention of late fentanyl-induced respiratory depression after the injection of opiate antagonists naltrexone and S-20682: comparison with naloxone

British Journal of Anaesthesia
E FreyeS Kaliebe


Compared with naloxone, two opiate antagonists (naltrexone and S-20682) were tested in the intact dog in order to reverse respiratory depression, induced by fentanyl 50 micrograms kg-1 i.v. Respiratory rate and arterial blood-gases were measured at 5, 30, 60, 120, 180 and 240 min after the additional i.v. injection of the antagonist (1 microgram kg-1). Only S-20682, but not naloxone or naltrexone, prevented late (240 min) fentanyl-induced depression of respiratory drive. A late respiratory depression coincided with an increase in amplitudes and a reduction of frequency in electrical cortical activity (EEG). Naltrexone exhibited an antagonistic effect of duration twice (60 min) that of naloxone.


Sep 1, 1986·Canadian Anaesthetists' Society Journal·F Donati
Nov 1, 1985·Canadian Anaesthetists' Society Journal·F M Ramsey, G D Smith
Jul 1, 1990·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·A SidiR F Davis
Aug 1, 1989·Anaesthesia and Intensive Care·P StaunC Lennmarken

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