Prevention of murine cardiac allograft rejection with gallium nitrate. Comparison with anti-CD4 monoclonal antibody

Transplantation
C G OroszN Gerber

Abstract

Gallium nitrate (GN) was evaluated for its ability to interfere with a cute rejection of DBA/2-->C57BL/6 heterotopic cardiac allografts, in comparison with the depleting anti-CD4 mAb, GK1.5. The administration of GN for 30 days (s.c. 30 mg/kg elemental gallium on days 0 and 3, 10 mg/kg every third day) resulted in >60-day graft survival in 78% (25 of 32) of the graft recipients, whereas 2 perioperative injections of anti-CD4 monoclonal antibody (mAb) resulted in >60-day graft survival in 58% (24 of 41) of the graft recipients. Serum gallium levels peaked at about 2000 ng/ml after 2-3 weeks of treatment and decreased to about 300 ng/ml by day 60, a level that was maintained for at least 30 more days. During the early posttransplant period, 25% of GN-treated grafts, but not anti-CD4 mAb-treated grafts, exhibited an unusual, transient reduction in graft impulse strength, suggesting a transient rejection response. Macroscopically, the long-surviving (>60 days) grafts from either treatment group exhibited none of the features of rejecting allografts. Histologically, they exhibited minor edema and rare epicardial inflammation but no tissue necrosis. However, there were vascular changes in allografts from GN-treated mice, including al...Continue Reading

References

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Citations

Oct 2, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·G L BumgardnerC G Orosz
Oct 9, 2002·Human Immunology·Alice Bickerstaff, Charles Orosz
Aug 16, 2002·Transplant Immunology·Alice A BickerstaffCharles G Orosz
Jul 18, 2002·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Meera J NathanD Keith Bishop
Oct 24, 2002·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Alice A BickerstaffCharles G Orosz
Jan 27, 1997·Transplantation·S D BergeseC G Orosz
Jan 1, 2005·Current Opinion in Oncology·Christopher R Chitambar
Oct 27, 2004·Transplantation·Keri E LunsfordGinny L Bumgardner
Sep 24, 2005·Transplantation·Sarah FaubelCharles L Edelstein
Jan 20, 2006·Transplantation·Kenneth A NewellAllan D Kirk
Jan 13, 2009·Transplantation·Bing HanBo Qu
Oct 27, 2009·Transplantation·Jean Kwun, Stuart J Knechtle
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Jun 28, 2018·Frontiers in Immunology·Johannes BaurAndris Avots

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