PMID: 3769187Nov 1, 1986Paper

Prevention of myocardial platelet deposition and thromboxane release with dipyridamole

Circulation
K H TeohA V Mee

Abstract

Although current methods of myocardial preservation for coronary bypass surgery provide excellent protection, perioperative ischemic injury persists. Platelet activation and myocardial deposition may contribute to perioperative ischemic injury and early postoperative graft occlusion. Dipyridamole may reduce platelet activation and myocardial deposition and reduce perioperative ischemic injury. A prospective randomized trial was instituted in 40 patients undergoing elective coronary bypass surgery to evaluate the effects of dipyridamole on myocardial platelet and leukocyte deposition and the cardiac release of thromboxane and prostacyclin. Twenty patients received intravenous dipyridamole (0.24 mg/kg/hr) beginning 20 hr before surgery and continuing for 24 hr after surgery. Autologous platelets, leukocytes, and erythrocytes were labeled with 111In, 99mTc, and 51Cr, respectively, and were infused before release of the cross-clamp. Myocardial biopsy samples were obtained 10, 20, and 30 min after aortic declamping and indicated that platelets and leukocytes were deposited in the myocardium during reperfusion. Dipyridamole reduced both platelet (with dipyridamole 1540 +/- 2100 cells/mg, no dipyridamole 14,500 +/- 33,000 cells/mg) an...Continue Reading

Related Concepts

Related Feeds

Cardiology Journals

Discover the latest cardiology research in this collection of the top cardiology journals.

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.