PMID: 11917205Mar 28, 2002Paper

Prevention of N-methyl-N'-nitro-N-nitrosoguanidine and saturated sodium chloride-induced gastric carcinogenesis in Wistar rats by lycopene

European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)
B VelmuruganS Nagini

Abstract

We investigated "the "chemopreventive potential of lycopene against gastric carcinogenesis induced in male Wistar rats by N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) and saturated sodium chloride (S-NaCl). Administration of lycopene inhibited MNNG+S-NaCl-induced gastric carcinogenesis as revealed by the absence of carcinomas. Lipid peroxidation, reduced glutathione (GSH), glutathione peroxidase (GPx), glutathione S-transferase (GST) and glutathione reductase (GR) were used to monitor the chemopreventive potential of lycopene. The extent of lipid peroxidation was significantly lower, whereas GSH, GPx, GST and GR were markedly enhanced in the gastric mucosa of tumour-bearing animals. Our data suggest that lycopene may exert its inhibitory effects by modulating the oxidant and antioxidant status in the gastric mucosa.

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Citations

Feb 16, 2010·Nutrition and Cancer·Karin Wertz
Jan 29, 2008·American Journal of Therapeutics·Soley SerenOmer Kucuk
Aug 24, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Cristina Trejo-SolísJulio Sotelo
Jan 19, 2007·Toxicology and Applied Pharmacology·Lili TangJia-Sheng Wang
Apr 15, 2004·Alimentary Pharmacology & Therapeutics·D M Pritchard, S M C Przemeck
Jun 21, 2008·International Journal of Cancer. Journal International Du Cancer·Fuzhi Lian, Xiang-Dong Wang
Jul 8, 2015·Journal of Cancer Prevention·Mi Jung Kim, Hyeyoung Kim
Jul 21, 2016·Central European Journal of Public Health·Milena IlićIrena Ilić
Dec 31, 2009·Phytotherapy Research : PTR·Anshoo MalhotraD K Dhawan
Jul 21, 2005·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·B VelmuruganS Nagini
Dec 1, 2004·The Journal of Nutrition·Jessica K CampbellJohn W Erdman
Jun 25, 2009·International Journal of Cancer. Journal International Du Cancer·Yan WangXiang-Dong Wang
Jul 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Boon-Peng PuahYusof Kamisah

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