Prevention of N-nitrosodiethylamine-induced hepatocarcinogenesis by S-allylcysteine

Molecular and Cellular Biochemistry
Sivapatham Sundaresan, Perumal Subramanian

Abstract

Chemopreventive effect of S-allylcysteine (constituent of garlic) on N-nitrosodiethylamine (NDEA)-induced hepatocarcinogenesis was evaluated in Wistar rats. Significantly decreased lipid peroxidation products (thiobarbituric acid reactive substances-TBARS and lipid hydroperoxides) with increased level of reduced glutathione, increased activities of glutathione S-transferase, and glutathione peroxidase were observed in liver of NDEA-treated rats when compared with control rats. The activities of superoxide dismutase and catalase were significantly decreased in tumor tissue when compared with control. Administration of S-allylcysteine (SAC) showed the inhibition of tumor incidence, modulated the lipid peroxidation, and increased the reduced glutathione, glutathione-dependent enzymes, superoxide dismutase, and catalase in NDEA-induced carcinogenesis. From our results, we speculate that S-allylcysteine mediates its chemopreventive effects by modulating lipid peroxidation, GST stimulation, and by increasing the antioxidants. Hence SAC prevents cells from loss of oxidative capacity in NDEA-induced hepatocarcinogenesis.

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Citations

Jul 11, 2012·The Journal of Pharmacy and Pharmacology·Talib HussainChandana Venkateswara Rao
Mar 23, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jen-Chieh TsaiChang-Wei Hsieh
Aug 28, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Arijit MondalAnupam Bishayee

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