Prevention of neomycin-induced nephrotoxic event in pig proximal tubular epithelial cell line by apolipoprotein E3

The Journal of Antibiotics
Kozo TakamotoDaishiro Ikeda

Abstract

Nephrotoxicity is one of critical problems of aminoglycoside antibiotics. We examined the protective effect of apolipoprotein E3 (apoE3), one of ligands for megalin, on neomycin-induced extracellular release of lactate dehydrogenase, a marker of cell necrosis using pig proximal tubular LLC-PK1 cells. Neomycin significantly induced the extracellular release of lactate dehydrogenase, but apoE3 successfully suppressed it. This result indicated that apoE3 protects the proximal tubular cells from the eventual cell death induced by nephrotoxic aminoglycosides.

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Citations

Oct 23, 2012·Trends in Molecular Medicine·Laure BidouOlivier Namy
Feb 13, 2022·Archives of Insect Biochemistry and Physiology·Gyanaseni DharMonalisa Mishra

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