Prevention of nephrotoxicity of ochratoxin A, a food contaminant

Toxicology Letters
E E CreppyA M Betbeder

Abstract

Ochratoxin A (OTA) is a mycotoxin produced by ubiquitous Aspergilli, mainly by Aspergillus ochraceus and also by Penicilium verrucosum. It was found all over the world in feed and human food and blood as well as in animal blood and tissues. The most threatening effects of OTA are its nephrotoxicity and carcinogenicity, since this mycotoxin is nephrotoxic to all animal species studied so far and is increasingly involved in the Balkan endemic nephropathy (BEN), a human chronic interstitial nephropathy which is most of the time associated to urinary tract tumours. Since it seems impossible to avoid contamination of foodstuffs by toxigenic fungi, detoxification and detoxication for OTA are needed. To reduce or abolish the OTA-induced toxic effects, several mechanisms were investigated. The results of these investigations showed that some of the potential antidotes were efficient in preventing the main OTA toxic effects whereas some others were not. Promising compounds are structural analogues of OTA, and/or compounds having a high binding affinity for plasma proteins such as piroxicam, a non-steroidal anti-inflammatory drug (NSAID). Some enzymes such as superoxide dismutase (SOD) and catalase, radical scavengers, vitamins, prostagl...Continue Reading

References

Apr 1, 1978·Canadian Journal of Microbiology·K Heller, Röschenthaler
Feb 1, 1979·Chemico-biological Interactions·E E CreppyG Dirheimer
Jul 28, 1978·Biochemical and Biophysical Research Communications·I BungeR Röschenthaler
Nov 1, 1976·Journal of Toxicology and Environmental Health·R E RanneyF G McMahon
Jul 1, 1989·Food Additives and Contaminants·C MiccoC Brera
Jan 1, 1989·Biochemical Pharmacology·S KhanA D Rahimtula
Dec 1, 1988·Biochemical Pharmacology·A D RahimtulaH Bartsch
Jul 2, 1974·Biochemistry·H Meisner, S Chan
Mar 13, 1965·Nature·K J van der MerweJ J Theron
Dec 1, 1965·Journal of the Chemical Society. Perkin Transactions 1·K J Van der MerweL Fourie
Nov 1, 1984·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·E E CreppyG Dirheimer
May 1, 1983·Archives of Biochemistry and Biophysics·H MeisnerR W Hanson
Apr 15, 1981·Archives of Biochemistry and Biophysics·H Meisner, P Meisner
Jul 1, 1980·Toxicology Letters·E E CreppyG Dirheimer
Apr 18, 1997·Chemico-biological Interactions·I BaudrimontE E Creppy

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Citations

Mar 1, 2002·Mycotoxin Research·Am Abdalla El-SayedAa Neamat-Allah
Apr 18, 1997·Chemico-biological Interactions·I BaudrimontE E Creppy
Nov 8, 2011·Chemical Research in Toxicology·Annie Pfohl-Leszkowicz, Richard A Manderville
Dec 8, 2005·Food Additives and Contaminants·Benoît SchilterChristophe Cavin
Apr 20, 2006·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Heather A Clark, Suzanne M Snedeker
Jun 13, 2001·Environmental Health Perspectives·R C Shoemaker, H K Hudnell
Nov 21, 1997·Emerging Infectious Diseases·J A Lindsay
Aug 4, 2015·Environment International·Ellen HeyndrickxSarah De Saeger
Oct 31, 2015·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Ran ChenHaoshu Luo
Feb 3, 2005·Journal of Pineal Research·Mosaad A Abdel-WahhabMohey El-Lithey
Sep 13, 2001·Food Additives and Contaminants·K Thirumala-DeviK E Emmanuel
Oct 3, 2006·Neurotoxicology and Teratology·Ritchie C Shoemaker, Dennis E House
Mar 17, 2007·International Journal of Toxicology·Emine SutkenOmer Colak
Apr 19, 2012·Journal of Biochemical and Molecular Toxicology·Zengning LiWeijun Kang
Mar 16, 2011·Critical Reviews in Toxicology·Sofia Cancela DuarteCeleste Matos Lino
Nov 24, 2004·Journal of Applied Toxicology : JAT·Huseyin OkutanNurten Ozcelik
Feb 24, 2001·Journal of Food Protection·F GalvanoG Galvano
Jun 14, 2002·Biochimica Et Biophysica Acta·Ellappan BabuHitoshi Endou
Aug 13, 2008·Toxicon : Official Journal of the International Society on Toxinology·Mosaad A Abdel-WahhabAziza A El-Nekeety

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