PMID: 8581777Sep 1, 1995Paper

Prevention of obesity in middle-aged monkeys: food intake during body weight clamp

Obesity Research
B C HansenN L Bodkin

Abstract

Prevention of obesity and increase in longevity in obesity-prone rodents can be achieved by long-term moderate dietary restriction. In order to examine the likelihood that caloric restriction could have similar salutary effects in humans, rhesus monkeys, after reaching mature adult stature, were placed on a protocol to clamp or stabilize body weight by weekly caloric adjustment. Furtherweight gain was prevented by this caloric titration procedure, and thus middle-age onset obesity, which is very common in this species, was prevented. The present study analyzed daily food intake for six weight-clamped monkeys and six ad libitum fed age-matched animals over a 3-year period, ages 18.5 to 21.5 years. After approximately 9 years of caloric restriction the daily calorie load to maintain stable adult body weight proved to be 40% less than the amount ingested by ad libitum fed animals. Calories per kg body weight did not differ significantly between the groups although the ad libitum fed animals were significantly fatter than the weight-clamped group. Prevention of obesity using this weight clamp protocol has also maintained lower insulin levels and higher glucose tolerance in the restricted animals.

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Citations

Oct 2, 1997·The New England Journal of Medicine·R Weindruch, R S Sohal
May 5, 2004·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Mark A LaneDonald K Ingram
Mar 18, 2011·ILAR Journal·Joseph W Kemnitz
Jul 5, 1996·Science·R S Sohal, R Weindruch
Jan 29, 2011·Journal of Biomedicine & Biotechnology·Keizo Kanasaki, Daisuke Koya
Jul 17, 1998·Aging : Clinical and Experimental Research·R J ColmanJ W Kemnitz
Mar 14, 2003·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Noni L BodkinBarbara C Hansen
Jun 29, 2002·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·R WeindruchS R Spindler
Aug 30, 2005·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Noni L BodkinBarbara C Hansen
Sep 6, 2012·Current Protocols in Pharmacology·Thomas A Lutz, Stephen C Woods
Sep 11, 2008·Laboratory Animals·John SpeakmanElzbieta Król
Aug 21, 2012·Antioxidants & Redox Signaling·Alejandro Martin-Montalvo, Rafael de Cabo
Jan 25, 2006·Journal of Medical Primatology·Tomoko TakahashiTakashi Kageyama
Feb 2, 2006·American Journal of Physiology. Endocrinology and Metabolism·Kristen J NadeauBoris Draznin
Nov 9, 2010·Oncogene·A Martín-MontalvoR de Cabo
Jul 4, 2001·The Journal of Biological Chemistry·K HottaY Matsuzawa
Mar 5, 2005·Reproduction, Fertility, and Development·Daniel A DumesicDavid H Abbott
Mar 8, 2002·American Journal of Physiology. Endocrinology and Metabolism·Lauren Jacobson
Feb 18, 2004·Journal of Endocrinological Investigation·A J van der Lely

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