Prevention of ocular scarring post glaucoma filtration surgery using the inflammatory cell and platelet binding modulator saratin in a rabbit model.

PloS One
Jeff MinMark B Sherwood

Abstract

Late complications can occur with use of current antimetabolites to prevent scarring following glaucoma filtration surgery (GFS). Safer, more targeted, anti-fibrosis agents are sought. The protein saratin has been shown to exhibit anti-fibrotic and anti-thrombotic properties in response to injury, but had not been used for glaucoma surgery. The goal of this study was to compare the efficacy of saratin with that of the widely accepted mitomycin-C (MMC) in prolonging bleb survival following GFS in the rabbit model. Two saratin delivery routes were compared; a single intraoperative topical application versus a combination of intraoperative topical application with two additional postoperative injections. Twenty-four New Zealand White rabbits underwent GFS and received either intraoperative topical saratin, intraoperative topical saratin plus two injections on post-operative days 4 and 8, balanced saline solution (BSS), or MMC. The bleb tissues and their elevation durations were compared based on clinical and histological findings. Rabbits receiving topical+injections of saratin had a mean bleb survival of 33.6±8.5 days, significantly higher than the negative BSS controls, which averaged 17.4±6.0 days (p = 0.018). No improvement ov...Continue Reading

References

Jan 1, 1994·Eye·G SchultzN Chegini
Jan 1, 1994·Eye·P T KhawG Larkin
Nov 14, 1997·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·M KnorrH J Thiel
Mar 7, 2002·Archives of Ophthalmology·Peter W DeBryLyndia C Brumback
Jul 3, 2002·Ophthalmology·Rajiv BindlishRichard Lehrer
Sep 25, 2002·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·G KrommesF Grehn
Jan 11, 2003·International Journal of Oral and Maxillofacial Surgery·A DugrillonH Klüter
Feb 13, 2003·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Che J Connon, Keith M Meek
Feb 28, 2003·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Henny J M BeckersCarroll A B Webers
Jul 18, 2003·Current Eye Research·Peter Oliver DenkMarcus Knorr
Jun 24, 2004·Thrombosis and Haemostasis·Gemma VilahurLina Badimon
Jul 15, 2004·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Elizabeth Draper Muckley, Richard A Lehrer
Sep 9, 2004·Journal of Glaucoma·M B SherwoodD A Samuelson
Feb 16, 2005·Archives of Ophthalmology·Brian A FrancisDon S Minckler
Apr 23, 2005·The Cochrane Database of Systematic Reviews·J BurrA Avenell
Jun 30, 2006·Journal of Thrombosis and Haemostasis : JTH·A BonnefoyM F Hoylaerts
Mar 8, 2007·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Ivan Goldberg, Robert Ritch
Apr 19, 2008·Investigative Ophthalmology & Visual Science·Tobias Meyer-Ter-VehnGünther Schlunck
Jul 1, 2008·Journal of Molecular Biology·Wolfram GronwaldHans Robert Kalbitzer
Dec 23, 2008·Investigative Ophthalmology & Visual Science·Yi-qin XiaoWen Ye
May 29, 2009·Investigative Ophthalmology & Visual Science·Zhongqiu LiIngeborg Stalmans
Jun 7, 2011·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Henry Ho-Lung Chan

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Citations

Oct 17, 2012·Survey of Ophthalmology·Leonard K SeiboldMalik Y Kahook
Mar 26, 2016·The Open Ophthalmology Journal·Masoumeh B MasoumpourM Reza Razeghinejad
Jun 7, 2020·International Ophthalmology·Camille Moura de Oliveira, Juliana de Lucena Martins Ferreira
Sep 30, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Tao GuanFeng Zhao
Sep 10, 2019·Journal of Current Glaucoma Practice·Cooper D RodgersMark B Sherwood

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Methods Mentioned

BETA
dissection
light microscopy

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