Prevention of pediatric graft coronary artery disease: atorvastatin

Pediatric Transplantation
Clifford ChinStanton B Perry

Abstract

Graft coronary artery disease is a significant cause of late graft failure and death after cardiac transplantation. HMG-coenzyme A reductase inhibitors have been used safely in children but their preventative effects against GCAD are not well known. We investigated whether atorvastatin when initiated early could prevent against the development of pediatric GCAD. Pediatric patients (transplanted between October 28, 1992 and July 9, 2004) were stratified into two groups based on whether or not they received atorvastatin early after transplant. Angiograms were reviewed by a single observer blinded to the treatment strategies and clinical outcomes. Actuarial survival method and the Mantel-Cox test were used to assess statistical significance. Freedom from GCAD was higher among those treated with atorvastatin early in the post-transplant course. One, three, and five-yr freedom from GCAD was significantly greater in the early treatment group (97%, 93%, and 93% respectively) compared with the control group (72%, 65%, and 60% respectively, p < 0.005). The early treatment group was also noted for fewer rejection episodes in the first post-transplant year. The use of atorvastatin when initiated early in the post-transplant course appears...Continue Reading

References

Sep 7, 1995·The New England Journal of Medicine·J A KobashigawaG A Cogert
Dec 16, 1997·American Heart Journal·B HeubleinA Haverich
Jul 25, 1998·The American Journal of Cardiology·P M WongG S Roubin
Mar 14, 2000·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·C L DentD T Balzer
Jun 19, 2001·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·M G PensonK O Schowengerdt
Nov 15, 2002·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Clifford ChinDaniel Bernstein
May 14, 2003·Circulation·Donna ManciniAndrew R Marks
Jan 18, 2005·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·William T MahleKirk R Kanter
Jun 14, 2005·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Elfriede PahlUNKNOWN Pediatric Heart Transplant Study
Jun 14, 2005·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Edythe B C ThamJeffrey A Feinstein
Aug 17, 2005·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·David O TaylorMarshall I Hertz
Aug 17, 2005·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Mark M BoucekMarshall I Hertz
Nov 22, 2005·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Jon A KobashigawaLawrence Yeatman

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Citations

Aug 29, 2014·Paediatric Drugs·Ingrid C GelissenRebekah Moles
Jan 30, 2016·Pediatric Transplantation·Sonia Marcos-AlonsoFrancisco Portela Torrón
Jan 10, 2016·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Steven C GreenwayYuk Law
Jul 21, 2010·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Maria Rosa CostanzoUNKNOWN International Society of Heart and Lung Transplantation Guidelines
Jun 20, 2008·Pediatric Transplantation·Mark R GoldsteinFrancesca Pezzetta
May 23, 2012·Congenital Heart Disease·Steven J Kindel, Elfriede Pahl
Jan 1, 2010·Dermato-endocrinology·Luca MascitelliMark R Goldstein
Apr 19, 2018·Pediatric Annals·Swati SehgalDeepak Kamat
Dec 26, 2018·Arteriosclerosis, Thrombosis, and Vascular Biology·Connie B NewmanUNKNOWN American Heart Association Clinical Lipidology, Lipoprotein, Metabolism and Thrombosis Committee, a Joint Committee of the C
Sep 29, 2019·The Journal of Pediatrics·Adriana H TremouletJane C Burns

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