Prevention of photoimmunosuppression and photocarcinogenesis by topical nicotinamide

Nutrition and Cancer
H L Gensler

Abstract

Ultraviolet (UV) B irradiation leads to a potent immunosuppression of the capacity to reject syngeneic, antigenic tumors. If this immunosuppression is critical for the development of most skin tumors, then its prevention should result in prevention of photocarcinogenesis. We previously showed a correlation between the inhibition of photoimmunosuppression and prevention of photocarcinogenesis by dl-alpha-tocopherol, tannic acid, or alpha-difluoromethylornithine. The current study was designed to determine whether topical nicotinamide, the active form of vitamin B-3, or niacin, prevents immunosuppression and skin cancer in UV-irradiated mice. In a passive transfer assay for immunosuppression, splenocytes from UV-irradiated mice enhanced the growth of antigenic tumor challenges in recipient mice. Treatment of the UV-irradiated mice with 40 mumol of nicotinamide twice weekly starting two weeks before UV irradiation and throughout the experiment prevented this immunosuppression. UVB irradiation consisted of five weekly 30-minute exposures to banks of six FS40 Westinghouse fluorescent sunlamps. Mice received approximately 6.2 x 10(5) J/m2 in the passive transfer assays and 1.09 x 10(6) J/m2 in the photocarcinogenesis studies. Applica...Continue Reading

References

Mar 1, 1991·Immunology Today·T R Mosmann, K W Moore
Sep 5, 1990·Journal of the National Cancer Institute·M L Kripke
Sep 1, 1990·Journal of the American Academy of Dermatology·R P GallagherL M Warshawski
Jan 1, 1980·European Heart Journal·S WinegradG McClellan
Nov 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·R A SederW E Paul
Dec 1, 1994·Journal of Leukocyte Biology·J M Rivas, S E Ullrich
Jan 1, 1997·CA: a Cancer Journal for Clinicians·S L ParkerP A Wingo

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Citations

Mar 8, 2005·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·C Bayerl
Apr 11, 2001·Mutation Research·G J Hageman, R H Stierum
Sep 6, 2001·Clinics in Dermatology·M P Lupo
Nov 19, 2002·Clinics in Dermatology·Ronni WolfBinnur Tüzün
May 3, 2003·Journal of Dermatological Science·Kwang Seok AhnYeong Shik Kim
Jun 3, 2000·Journal of Photochemistry and Photobiology. B, Biology·M Berneburg, J Krutmann
Oct 31, 2001·Journal of Photochemistry and Photobiology. B, Biology·E L JacobsonM K Jacobson
Jul 21, 2005·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Donald L BissettCynthia A Berge
May 25, 2010·Photochemistry and Photobiology·Joohong ParkDiona L Damian
Aug 21, 2010·Journal of Nucleic Acids·Devita SurjanaDiona L Damian
Sep 21, 2007·The Journal of Investigative Dermatology·Diona L DamianGary M Halliday
Jun 11, 2005·Experimental Dermatology·Amanda GreatensRaymond E Boissy
Apr 6, 2005·International Journal of Dermatology·Yoshinao SomaMasako Mizoguchi
May 22, 2008·International Journal of Cosmetic Science·D L BissettC A Berge
May 22, 2008·International Journal of Cosmetic Science·N OtteH C Korting
Dec 7, 2006·Journal of Cosmetic Dermatology·W Gehring
Jan 5, 2008·International Journal of Dermatology·Mohammad R Namazi
Jun 20, 2012·The British Journal of Dermatology·S M ThanosD L Damian
Aug 24, 2012·Dermatologic Therapy·John E Oblong
Jun 29, 2013·The British Journal of Dermatology·H A Rovito, J E Oblong
Dec 10, 2013·Photodermatology, Photoimmunology & Photomedicine·Andrew C ChenGary M Halliday
Mar 19, 2014·The Australasian Journal of Dermatology·Andrew C Chen, Diona L Damian
Nov 29, 2013·Photodermatology, Photoimmunology & Photomedicine·Suzanne M PilkingtonLesley E Rhodes
Oct 24, 2006·Seminars in Cutaneous Medicine and Surgery·Christine M Choi, Diane S Berson
Nov 4, 2000·Dermatologic Clinics·Z D Draelos
Aug 9, 2011·Dermatology Research and Practice·Josefina Navarrete-SolísBenjamin Moncada
Jun 8, 2013·Pharmaceutical Development and Technology·Sakine Tuncay, Özgen Özer
Jul 9, 2002·The British Journal of Dermatology·T HakozakiR E Boissy
Feb 6, 2017·International Journal of Cancer. Journal International Du Cancer·Sang Min ParkEunyoung Cho
Apr 7, 2006·International Journal of Toxicology·UNKNOWN Cosmetic Ingredient Review Expert Panel
Aug 24, 1999·Nutrition and Cancer·H L GenslerE L Jacobson
Aug 23, 2018·Journal of Cosmetic Dermatology·Mohammad Ali NilforoushzadehMahsa Mollapour Sisakht
Jan 31, 2019·Experimental Dermatology·Victoria A SnaidrGary M Halliday
Apr 1, 2010·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Diona L Damian
Feb 26, 2019·Journal of the European Academy of Dermatology and Venereology : JEADV·A RosenthalJ Herrmann
Nov 11, 2009·Journal of Wound Care·P D ChakrabortyD Bhattacharyya
May 10, 2020·British Journal of Pharmacology·Aitziber BuquéLorenzo Galluzzi

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