PMID: 6965335Jan 1, 1980Paper

Prevention of pneumocystis pneumonia. Use of continuous sulfamethoxazole-trimethroprim therapy

American Journal of Diseases of Children
R E HarrisR L Baehner

Abstract

Owing to a 15% attack rate of Pneumocystis carinii pneumonitis (PCP) among the leukemic population of Riley Hospital, Indianapolis, a two-year study using continuous low-dosage sulfamethoxazole-trimethoprim to prevent PCP was started in January 1977. A total of 229 pediatric cancer patients considered at high risk for getting PCP received prophylaxis, while 19 additonal low-risk cancer patients did not receive sulfamethoxazole-trimethoprim. None of these 248 patients contracted PCP. However, five cases of PCP did occur among ten additional high-risk patients who failed to receive this preparation for a variety of reasons. Complications of the continuous prophylaxis program included neutropenia, rash, and gastrointestinal complaints. This study confirms that continuous, low-dosage sulfamethoxazole-trimethoprim prophylaxis is effective in preventing PCP in susceptible immunosuppressed patients but is ineffective in eradicating the organism from the population at risk.

Citations

Jul 1, 1981·The Journal of Pediatrics·R J LeggiadroW T Hughes
Mar 1, 1983·La Revue de médecine interne·C MayaudJ Roland
Mar 8, 2017·Journal of Pediatric Hematology/oncology·Rebecca ProudfootSophie Wilne
Apr 27, 2007·Pediatric Blood & Cancer·Pinki PrasadSadhna M Shankar
Jan 1, 1981·American Journal of Medical Genetics·R E HarrisM E Hodes
Aug 1, 1986·European Journal of Pediatrics·S Ozsoylu, N Koçak
Sep 1, 1980·Indian Journal of Pediatrics·V P Choudhry, J P Wali
May 1, 1992·Transplant International : Official Journal of the European Society for Organ Transplantation·C G ElinderG Tydén
May 26, 2018·The Pediatric Infectious Disease Journal·Kengo InagakiCharlotte V Hobbs
Oct 12, 2007·Paediatric Drugs·Sadhna M Shankar, Joseph J Nania
Sep 27, 2015·Archives of Disease in Childhood·Alison BoastAmanda Gwee
Jan 1, 1986·Scandinavian Journal of Infectious Diseases·O P Settnes, J Genner
Aug 1, 1985·Thorax·J T Macfarlane, R G Finch
Jan 1, 1984·Journal of the Association of Pediatric Oncology Nurses·R F Kramer
Oct 1, 1981·Drug Intelligence & Clinical Pharmacy·J F JohnsonG F Moore
Oct 1, 1999·Paediatrics & Child Health
Jun 25, 1987·The New England Journal of Medicine·W T HughesL Lott
Feb 27, 2021·Archives of Disease in Childhood·Rebecca Hilary Proudfoot, Bob Phillips

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