PMID: 8582983Jul 1, 1995Paper

Prevention of post-surgical adhesion formation using aspirin in a rodent model: a preliminary report

Human Reproduction
A GolanI Bukovsky

Abstract

Pelvic adhesions are one of the major factors which significantly and adversely affect surgery outcome due to intra- and postoperative morbidity and reduce future female fertility. Using a rodent model, we evaluated the efficacy of aspirin, a non-steroidal anti-inflammatory drug, in the prevention of adhesion formation. A total of 72 female Wistar rats received a standardized primary traumatic lesion to the right uterine horn. They were randomly divided into eight groups: group I (control) had no treatment and group II received a single pre-operative 0.70 mg aspirin. All the succeeding groups (III-VIII) received aspirin in doses of 0.35, 0.70, or 1.40 mg every 6 h for either 48 or 96 h in addition to the pre-operative aspirin (0.70 mg). All animals were killed 4 weeks later and adhesions were assessed using a modified adhesion scoring scale. The lowest adhesion score was found in the group treated with 0.35 mg of aspirin for 96 h, and the highest was found among the groups treated with either 0.70 or 1.40 mg for 48-96 h respectively (P < 0.05). These results are in line with the hypothesis that administration of a low dose of aspirin selectively inhibits the production of thromboxane A2, whereas basal prostacyclin biosynthesis ...Continue Reading

Citations

Aug 10, 2013·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Willy ArungOlivier Detry
Apr 25, 2007·Human Reproduction Update·C NappiG Bifulco
Jan 4, 2008·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Manuel A Sandoval, Daniel Hernandez-Vaquero
Oct 19, 2007·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Yusuf UstünAyse Kafkasli
Aug 21, 2015·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Gokalp OnerCemal Gündogdu
Jan 22, 2010·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Mark A SuckowAbram D Janis
Jan 5, 2013·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·A L Behçetİbrahim Sarı
Jul 12, 2020·Materials·Heekyung ParkDonghyun Lee
Dec 29, 1999·Diseases of the Colon and Rectum·P J KlinglerP P Metzger

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