PMID: 8958125Jan 1, 1997Paper

Prevention of postasphyxia electroretinal dysfunction with a pyridoxal hydrazone

Free Radical Biology & Medicine
M BhattacharyaS Chemtob

Abstract

The newborn retina is particularly sensitive and frequently subjected to peroxidative stresses that result in visual sequelae. We compared two iron chelators, deferoxamine and a newer compound, pyridoxal isonicotinoyl hydrazone (PIH), in protecting the retina of newborn pigs (1-3 d old) from asphyxia-reoxygenation insults. Animals were treated IV with either saline, deferoxamine 15.2 mumol/kg (10 mg/kg) or PIH 34.8 mumol/kg (10 mg/kg); n = 10 in each treatment group. Scotopic and photopic electroretinograms (ERG) were recorded before and 40 min after drug treatment as well as 45 min following a 5-min period of asphyxia by interrupting ventilation. In separate animals the indices of peroxidation, malondialdehyde (MDA: TBARS) and hydroperoxides, were measured in retina at the same times. In saline-treated animals, there was a marked increase in MDA and hydroperoxide concentrations in the retina following the asphyxia-reoxygenation period. This was associated with a decrease in the a- (photoreceptor generated) and b-wave (generated by Müller and bipolar cells) amplitudes measured under photopic (cone-mediated response) and scotopic (rod-mediated response) conditions, and an increase in their implicit times. PIH and deferoxamine pr...Continue Reading

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Citations

Feb 22, 2003·Biochimica Et Biophysica Acta·Angelo Q MaurícioMarcelo Hermes-Lima
Oct 22, 2009·Redox Report : Communications in Free Radical Research·Senti T SenthilmohanMurray J McEwan
Feb 18, 2016·Oxidative Medicine and Cellular Longevity·Jesús Pérez-HernándezAnahí Chavarría
Jan 22, 2005·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·T SimůnekP Ponka
Aug 3, 2005·Journal of Pharmaceutical and Biomedical Analysis·P KovaríkováK Vávrová

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