Prevention of posterior capsular opacification

Experimental Eye Research
Lisanne M NibourgSteven A Koopmans

Abstract

Posterior capsular opacification (PCO) is a common complication of cataract surgery. The development of PCO is due to a combination of the processes of proliferation, migration, and transdifferentiation of residual lens epithelial cells (LECs) on the lens capsule. In the past decades, various forms of PCO prevention have been examined, including adjustments of techniques and intraocular lens materials, pharmacological treatments, and prevention by interfering with biological processes in LECs. The only method so far that seems effective is the implantation of an intraocular lens with sharp edged optics to mechanically prevent PCO formation. In this review, current knowledge of the prevention of PCO will be described. We illustrate the biological pathways underlying PCO formation and the various approaches to interfere with the biological processes to prevent PCO. In this type of prevention, the use of nanotechnological advances can play a role.

References

Nov 1, 1994·Journal of Cataract and Refractive Surgery·T IshibashiH Inomata
Jul 1, 1993·Journal of Cataract and Refractive Surgery·U F LeglerS L Mowbray
Jan 1, 1996·Journal of Cataract and Refractive Surgery·M PandeJ Marshall
Mar 1, 1997·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·P CortinaM Diaz-Llopis
Jan 1, 1996·Journal of Cataract and Refractive Surgery·O NishiK Sakanishi
Sep 1, 1997·Nature Medicine·G DuncanP D Davies
Feb 11, 1998·Journal of Cataract and Refractive Surgery·I F HepsenC Evereklioglu
Oct 13, 1998·Journal of Cataract and Refractive Surgery·S SaikaA Yamanaka
Jan 8, 1999·Experimental Eye Research·N IbarakiV N Reddy
Jul 15, 1999·Journal of Cataract and Refractive Surgery·R H BrettonR Cooley
Aug 13, 1999·Journal of Cataract and Refractive Surgery·H BirinciE Acar
Jan 11, 2000·Eye·J M Marcantonio, G F Vrensen
Feb 23, 2000·Journal of Cataract and Refractive Surgery·X H ZhangJ Q Yuan
Feb 24, 2000·The British Journal of Ophthalmology·W R MeacockM R Stanford
Oct 18, 2000·Journal of Cataract and Refractive Surgery·O NishiK Wickström
Feb 15, 2001·International Journal of Radiation Oncology, Biology, Physics·A M JoussenB Kirchhof
Aug 8, 2001·Journal of Cataract and Refractive Surgery·S SaikaA Ooshima
Aug 8, 2001·Journal of Cataract and Refractive Surgery· Inan UUC Güler
Aug 29, 2001·Journal of Cataract and Refractive Surgery·X H ZhangJ Q Yuan
Nov 2, 2001·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·U U InanC Güler
Jan 5, 2002·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·F T GeisslerE R James
Jan 30, 2002·The British Journal of Ophthalmology·Frank J LovicuJohn W McAvoy
Mar 22, 2002·Progress in Retinal and Eye Research·Jeremy M Sivak, M Elizabeth Fini
May 17, 2002·Experimental Eye Research·I Michael Wormstone
Aug 6, 2002·Journal of Cataract and Refractive Surgery·Shizuya SaikaAkira Ooshima
Apr 26, 2003·Investigative Ophthalmology & Visual Science·Shizuya SaikaWinston W-Y Kao
Apr 30, 2003·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Lixin XieZhan Yao
Jun 18, 2003·Cell·Yigong Shi, Joan Massagué
Aug 9, 2003·Experimental Eye Research·J M MarcantonioG Duncan
Sep 5, 2003·Journal of Cataract and Refractive Surgery·Gisela WejdeCharlotta Zetterström
Sep 5, 2003·Journal of Cataract and Refractive Surgery·Anthony MaloofSuresh K Pandey
Dec 18, 2003·The Journal of Clinical Investigation·Raghu Kalluri, Eric G Neilson
Jan 27, 2004·The American Journal of Pathology·Shizuya SaikaAnita B Roberts
Apr 27, 2004·Experimental Eye Research·I M WormstoneG Duncan
May 8, 2004·Journal of Cataract and Refractive Surgery·Jonathan G CrowstonAnthony Maloof
Jul 28, 2004·Investigative Ophthalmology & Visual Science·Jongkyu ChoiChoun-Ki Joo
Dec 25, 2004·Journal of Cataract and Refractive Surgery·Viviana FernandezJean-Marie Parel

❮ Previous
Next ❯

Citations

Jan 21, 2017·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Xuan BaoMingxing Wu
Feb 7, 2017·Clinical & Experimental Ophthalmology·Chu Luan Nguyen, Ian C Francis
Jul 20, 2018·Investigative Ophthalmology & Visual Science·Leonid M ZukinJ Mark Petrash
Dec 7, 2018·Investigative Ophthalmology & Visual Science·Laura WerneckeDaniel J Salchow
Jan 9, 2019·PloS One·Meng-Yao HanJiang-Bo Ren
Feb 16, 2019·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·A Sue MenkoMary Ann Stepp
Apr 11, 2019·The Journal of Pharmacology and Experimental Therapeutics·Carmen Alvarez-Lorenzo, Angel Concheiro
Jun 22, 2019·Journal of Translational Medicine·Hung-Chi ChenShun-Fa Yang
May 12, 2018·International Journal of Molecular Medicine·Fanlan MengXin Tang
Nov 9, 2018·Journal of Cell Science·Judy K VanSlykeLinda S Musil
Feb 9, 2018·Zeitschrift für Gesundheitswissenschaften = Journal of public health·Nils KossackDennis Häckl
Apr 11, 2019·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Jaime JavaloyStephanie Rohrweck
May 3, 2019·Investigative Ophthalmology & Visual Science·Jacquelyn GerhartMindy George-Weinstein
Oct 19, 2016·Acta Ophthalmologica·Lisanne M NibourgSteven A Koopmans
Oct 17, 2018·Investigative Ophthalmology & Visual Science·Jian JiangMelinda K Duncan
Mar 17, 2016·Journal of Biomaterials Applications·Xu XuQuan-Kui Lin
Dec 25, 2019·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Justine VietCarole Gautier-Courteille
May 14, 2020·Science China. Life Sciences·Jinda WangXiuhua Wan
Oct 31, 2020·Current Opinion in Ophthalmology·Majid MoshirfarShannon E McCabe
Jan 26, 2021·Journal of Ophthalmology·Yingying HongYinghong Ji
Apr 19, 2021·International Journal of Pharmaceutics·Ana TopeteAna Paula Serro
Sep 26, 2020·Progress in Retinal and Eye Research·I M WormstoneJ A Eldred
Jul 3, 2021·Journal of Clinical Medicine·Joanna KonopińskaIwona Obuchowska

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

AKT Pathway

This feed focuses on the AKT serine/threonine kinase, which is an important signaling pathway involved in processes such as glucose metabolism and cell survival.

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis