PMID: 2121563Dec 1, 1990Paper

Prevention of postoperative adhesions by tissue-type plasminogen activator (t-PA) in the rabbit

European Journal of Obstetrics, Gynecology, and Reproductive Biology
P J DörrR Rolland

Abstract

The fibrinolytic system of the peritoneum is important in the pathogenesis of adhesions. Plasminogen activator activity is depressed by serosal types of injury, which cause ischemia. Ischemic peritoneum induces fibrinous adhesions. When local fibrinolytic activity is impaired, persistence of fibrin and organisation of the fibrinous adhesions may occur. Peritoneal adhesion in rabbits were created by drying the serosa of the uterine horns and by introducing a small amount of blood intraperitoneally. In one group of rabbits tissue-type plasminogen activator (t-PA) was given intraperitoneally at the end of the operation: another group served as controls. 48 rabbits were operated on. The animals were killed 3 h, 1, 3 and 7 days postoperatively for evaluation of adhesions. All animals of the control group had adhesions. The animals of the t-PA group had less adhesions than the animals of the control group.

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Citations

Aug 19, 2008·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Rizal LimJames M Becker
Feb 3, 2012·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Christoph BrochhausenC James Kirkpatrick
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Aug 6, 2000·Fertility and Sterility·B W HellebrekersT Kooistra
Feb 2, 2013·World Journal of Emergency Surgery : WJES·Federico CoccoliniFausto Catena
Dec 16, 2011·World Journal of Gastroenterology : WJG·Hussein M Atta
May 6, 2014·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Ahmet SahbazBanu Dogan Gun
Apr 13, 2010·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Remah M Kamel
Dec 17, 2008·Annals of the New York Academy of Sciences·Karen L ReedJames M Becker
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Nov 24, 2004·The Journal of the American Association of Gynecologic Laparoscopists·Ghassan M Saed, Michael P Diamond
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May 20, 2014·The Journal of Surgical Research·Michael R CassidyArthur F Stucchi
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Sep 13, 2006·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Cem BatukanIptisam I Muderris
Jul 28, 2020·The Journal of Surgical Research·Colton BoudreauMichael Bezuhly

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