PMID: 16538123Mar 16, 2006Paper

Prevention of postoperative recurrence of Crohn's disease by infliximab

European Journal of Gastroenterology & Hepatology
Dario SorrentinoFrancesco Toso

Abstract

The prevention of the recurrence of Crohn's disease after surgery remains difficult. The monoclonal antibody anti-TNF-alpha, infliximab, is very effective in inducing and maintaining the remission of uncomplicated, active Crohn's disease. We present here the case of a 23-year-old white woman who underwent resection for a sigmoid stricture caused by Crohn's disease. Surgery removed the involved colon, and pathology confirmed the stricture to be fibrotic. Two weeks after the operation she was given infliximab at the dose of 5 mg/kg body weight and followed in time. Since then, she has been disease free for approximately 4 years after surgery on clinical, radiological and endoscopic/histological grounds (Crohn's Disease Activity Index < or = 110 on all occasions). Up to now, she has had no increase in inflammatory indices, no anaemia and no abnormal blood tests. In contrast, all of five control patients operated in the same period with colonic or ileocolonic resection for symptomatic strictures and treated with mesalamine or no medication developed endoscopic or clinical recurrence (abdominal pain or diarrhoea) by year 3. This is the first case, to our knowledge, in which infliximab has been successfully used to prevent the postsu...Continue Reading

References

Jan 1, 1990·The Medical Clinics of North America·D B Sachar
Sep 14, 2004·Gastroenterology·Sandro ArdizzoneGabriele Bianchi Porro

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Citations

Oct 24, 2008·Inflammatory Bowel Diseases·Eric Blum, Jeffry A Katz
Mar 27, 2009·Inflammatory Bowel Diseases·Miguel Regueiro
Jun 17, 2008·International Journal of Colorectal Disease·M KraemerT Marth
May 5, 2012·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Yi LiJieshou Li
Nov 14, 2008·Current Gastroenterology Reports·Bo Shen
May 8, 2013·Nature Reviews. Gastroenterology & Hepatology·Dario Sorrentino
Feb 2, 2008·Digestion·Florian FroehlichJean-Jacques Gonvers
Apr 2, 2011·European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes·G SciaudoneF Selvaggi
Jan 21, 2014·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Miguel RegueiroWolfgang Schraut
Feb 9, 2010·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Dario SorrentinoDimitra Zarifi
Dec 27, 2008·Gastroenterology·Miguel RegueiroScott E Plevy
Jul 5, 2008·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·D SorrentinoC Avellini
May 1, 2015·Journal of Crohn's & Colitis·Marc FerranteUNKNOWN International Organization for Study of Inflammatory Bowel Diseases
Mar 8, 2016·Gastroenterology·Miguel RegueiroUNKNOWN PREVENT Study Group
Sep 30, 2016·Expert Review of Gastroenterology & Hepatology·Vu NguyenDario Sorrentino
May 9, 2014·Expert Review of Gastroenterology & Hepatology·Zhiping YangDaiming Fan
Aug 11, 2011·Inflammatory Bowel Diseases·Peter De CruzPaul V Desmond
Mar 29, 2008·The American Journal of Gastroenterology·Siew C Ng, Michael A Kamm
Jun 3, 2009·Expert Review of Gastroenterology & Hepatology·Sandra El-Hachem, Miguel Regueiro
Oct 29, 2013·Expert Review of Gastroenterology & Hepatology·Dario SorrentinoJohan Van den Bogaerde
Jul 25, 2019·The Cochrane Database of Systematic Reviews·Sangmin LeeM Ellen Kuenzig
Oct 13, 2009·The Cochrane Database of Systematic Reviews·Glen DohertyAlan C Moss
Jan 27, 2019·Digestive Diseases and Sciences·Christine A SchadAndrea C Bafford
Jun 8, 2018·Digestive Diseases and Sciences·Shirley Cohen-MekelburgAdam Steinlauf
Nov 18, 2017·Digestive Diseases and Sciences·Vu Q NguyenDario Sorrentino
Apr 4, 2018·The American Journal of Gastroenterology·Gary R LichtensteinBruce E Sands
Oct 3, 2020·Annals of Gastroenterological Surgery·Dallas D Wolford, Alessandro Fichera

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