PMID: 15229064Jul 2, 2004Paper

Prevention of postpartum depression: a pilot randomized clinical trial

The American Journal of Psychiatry
Katherine L WisnerRobert L Findling

Abstract

The authors attempted to reduce the rate of postpartum depression in high-risk women and to increase the time to recurrence. Nondepressed pregnant women with at least one past episode of postpartum major depression were recruited into a randomized clinical trial. Mothers were assigned randomly to a 17-week trial of sertraline or placebo immediately after birth and assessed for 20 sequential weeks with the Hamilton Rating Scale for Depression. Of 14 subjects who took sertraline, one (7%) suffered a recurrence. Of eight subjects who were assigned to placebo, four (50%) suffered recurrences. This difference was significant. The time to recurrence was significantly longer in the sertraline-treated women than in the placebo-treated women. Sertraline conferred preventive efficacy for postpartum-onset major depression beyond that of placebo.

Citations

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Apr 8, 2009·Archives of Women's Mental Health·Diane F HunkerKatherine L Wisner
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