Prevention of poststroke depression: does prophylactic pharmacotherapy work?

Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association
Katherine L SalterRobert Teasell

Abstract

Given the negative influence of poststroke depression (PSD) on functional recovery, cognition, social participation, quality of life, and risk for mortality, the early initiation of antidepressant therapy to prevent its development has been investigated; however, individual studies have offered conflicting evidence. The present systematic review and meta-analysis examined available evidence from published randomized controlled trials (RCTs) evaluating the effectiveness of pharmacotherapy for the prevention of PSD to provide updated pooled analyses. Literature searches of 6 databases were performed for the years 1990 to 2011. RCTs meeting study inclusion criteria were evaluated for methodologic quality. Data extracted included the antidepressant therapy used, treatment timing and duration, method(s) of assessment, and study results pertaining to the onset of PSD. Pooled analyses were conducted. Eight RCTs were identified for inclusion. Pooled analyses demonstrated reduced odds for the development of PSD associated with pharmacologic treatment (odds ratio [OR] 0.34; 95% confidence interval [CI] 0.22-0.53; P<.001), a treatment duration of 1 year (OR 0.31; 95% CI 0.18-0.56; P<.001), and the use of a selective serotonin reuptake inh...Continue Reading

References

Feb 1, 1995·JAMA : the Journal of the American Medical Association·K F SchulzD G Altman
Oct 6, 1997·BMJ : British Medical Journal·M EggerC Minder
Mar 24, 2000·Journal of Clinical Epidemiology·A Thornton, P Lee
May 16, 2002·The Journal of Nervous and Mental Disease·Kenji NarushimaRobert G Robinson
Jul 16, 2003·Archives of General Psychiatry·Dennis S CharneyUNKNOWN Depression and Bipolar Support Alliance
Jan 7, 2004·Cerebrovascular Diseases·Jean-François SpielerPierre Amarenco
Apr 17, 2004·Journal of the American Geriatrics Society·Ellen M WhyteMary Ganguli
May 5, 2004·The British Journal of Psychiatry : the Journal of Mental Science·T B UstünC J L Murray
Jan 12, 2005·The Journal of Clinical Psychiatry·Nikolaj NiedermaierIsabella Heuser
Apr 5, 2005·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·A WardP L Kolominsky-Rabas
May 10, 2005·Stroke; a Journal of Cerebral Circulation·Maree L HackettCraig S Anderson
Oct 22, 2005·Lancet Neurology·Didier LeysFlorence Pasquier
Jun 13, 2006·Journal of Neurology·Stefano PaolucciUNKNOWN DESTRO Study Group
Jun 24, 2006·Stroke; a Journal of Cerebral Circulation·Maree L HackettUNKNOWN Auckland Regional Community Stroke (ARCOS) Study Group
Jul 22, 2006·International Journal of Geriatric Psychiatry·Ellen M Whyte, Barry Rovner
Sep 30, 2006·Stroke; a Journal of Cerebral Circulation·Huanguang JiaLinda S Williams
Apr 7, 2007·International Clinical Psychopharmacology·Yan ChenSiyan Zhan
May 23, 2007·International Journal of Epidemiology·J PildalP C Gøtzsche
Jun 19, 2007·Topics in Stroke Rehabilitation·Katherine SalterRobert Teasell
Dec 13, 2007·Physical Therapy·Susan Armijo OlivoDavid J Magee
May 29, 2008·JAMA : the Journal of the American Medical Association·Robert G RobinsonStephan Arndt
May 2, 2009·Stroke; a Journal of Cerebral Circulation·William E HaleyDavid L Roth
May 29, 2009·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·A KyrozisK N Vemmos
Jan 1, 2001·Nursing Research·C S TeelS M Lai
Oct 17, 2009·The American Journal of Psychiatry·Jeffrey M LynessYeates Conwell
Jan 23, 2010·Stroke; a Journal of Cerebral Circulation·Maree L HackettUNKNOWN Stroke Outcomes Study Group
Feb 2, 2010·General Hospital Psychiatry·Ulrike SagenToril Dammen
Aug 4, 2011·BMJ : British Medical Journal·Carol CouplandJulia Hippisley-Cox

❮ Previous
Next ❯

Citations

Oct 1, 2013·European Archives of Psychiatry and Clinical Neuroscience·Julian Hellmann-RegenChristian Otte
Feb 18, 2016·Disability and Rehabilitation·Julianne VermeerRobert Teasell
Dec 29, 2015·PM & R : the Journal of Injury, Function, and Rehabilitation·Heidi SchambraMichael W O'Dell
Feb 3, 2015·Acta Neurologica Scandinavica·R-J KoivunenJ Putaala
Mar 28, 2017·Expert Review of Neurotherapeutics·Melissa JonesRicardo E Jorge
May 24, 2017·Expert Opinion on Pharmacotherapy·Stefano Paolucci
Mar 29, 2014·Stroke; a Journal of Cerebral Circulation·Robert G HollowayUNKNOWN American Heart Association Stroke Council, Council on Cardiovascular and Stroke Nursing, and Council on Clinical Cardiology
Jan 27, 2017·Circulation·Emelia J BenjaminUNKNOWN American Heart Association Statistics Committee and Stroke Statistics Subcommittee
Feb 2, 2018·Circulation·Emelia J BenjaminUNKNOWN American Heart Association Council on Epidemiology and Prevention Statistics Committee and Stroke Statistics Subcommittee
Jul 1, 2017·Stroke; a Journal of Cerebral Circulation·Thomas P C Dorlo
Dec 10, 2016·Stroke; a Journal of Cerebral Circulation·Amytis TowfighiUNKNOWN American Heart Association Stroke Council; Council on Cardiovascular and Stroke Nursing; and Council on Quality of Care and
Feb 1, 2019·Circulation·Emelia J BenjaminUNKNOWN American Heart Association Council on Epidemiology and Prevention Statistics Committee and Stroke Statistics Subcommittee
Jan 30, 2020·Circulation·Salim S ViraniUNKNOWN American Heart Association Council on Epidemiology and Prevention Statistics Committee and Stroke Statistics Subcommittee
Jun 27, 2019·Current Treatment Options in Neurology·Sergio E Starkstein, Bradleigh D Hayhow
Jun 22, 2019·International Journal of Stroke : Official Journal of the International Stroke Society·Krista L LanctôtUNKNOWN Management of Mood, Cognition and Fatigue Following Stroke Best Practice Writing Group, the Heart & Stroke Canadian Stroke B
Dec 21, 2019·Expert Review of Neurotherapeutics·Luis Castilla-GuerraMiguel Angel Colmenero-Camacho
May 12, 2020·The Cochrane Database of Systematic Reviews·Sabine AllidaMaree L Hackett
Dec 12, 2019·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·N A Trusova, O S Levin
May 27, 2020·Health Technology Assessment : HTA·Martin DennisGillian Mead
Oct 26, 2018·Current Neurology and Neuroscience Reports·F CholletI Loubinoux
Nov 13, 2020·American Journal of Speech-language Pathology·Jacqueline S Laures-GoreSamir Belagaje
Jan 28, 2021·Circulation·Salim S ViraniUNKNOWN American Heart Association Council on Epidemiology and Prevention Statistics Committee and Stroke Statistics Subcommittee
Jan 30, 2021·Seminars in Neurology·Katlyn Nemani, Lindsey Gurin
Feb 4, 2021·Expert Opinion on Pharmacotherapy·Janne Kaergaard Mortensen, Grethe Andersen
Nov 13, 2017·Pharmacology & Therapeutics·Roberto Federico VillaAntonio Moretti
May 16, 2021·Practical Neurology·João Facucho-OliveiraFernando Pita
Aug 11, 2021·Journal of Affective Disorders·Gonzalo Salazar de PabloPaolo Fusar-Poli

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Current Psychiatry Reports
Haresh M TharwaniPrakash Masand
Expert Opinion on Pharmacotherapy
Rajamannar Ramasubbu
Current Neurology and Neuroscience Reports
F CholletJ Pariente
© 2021 Meta ULC. All rights reserved