PMID: 9540946Apr 16, 1998Paper

Prevention of preeclampsia by linoleic acid and calcium supplementation: a randomized controlled trial

Obstetrics and Gynecology
J A HerreraS Herrera

Abstract

To determine the effect of low doses of linoleic acid and calcium on prostaglandin (PG) levels and the efficacy of this treatment in the prevention of preeclampsia. In a randomized, double-blind, placebo-controlled study we treated 86 primigravidas with risk factors for preeclampsia (high biopsychosocial risk [above 3 points], positive roll-over test, and high mean blood pressure [above 85 mmHg)] with daily doses of either 450 mg linoleic acid and 600 mg calcium (n=43) or 450 mg starch and 600 mg lactose placebo (n=43) during the third trimester of pregnancy. Four women in the experimental group (9.3%) developed preeclampsia compared with 16 (37.2%) controls (relative risk 0.25, 95% confidence interval 0.09, 0.69, P < .001). The median serum levels of PGE2 after 4 weeks of treatment increased by 106% in the experimental group (P=.03) and decreased by 33% in the control group (P=.02). The median ratio between thromboxane B2 and PGE2 decreased by 40% in the experimental group (P=.02) and increased by 18% in the control group (P=.14). No significant differences were observed in the median ratio between thromboxane B2 and 6-keto PGF1alpha in either group. No serious maternal or neonatal side effects of treatment occurred in either ...Continue Reading

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Citations

Feb 16, 1999·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·R KulierJ Villar
Jan 14, 2000·Journal of Nurse-midwifery·M A Kelley
Apr 29, 1999·Current Opinion in Obstetrics & Gynecology·D O Anumba, S C Robson
Aug 19, 1999·Clinical Obstetrics and Gynecology·E R NorwitzJ T Repke
Nov 13, 2009·Nutrition Reviews·Hairong XuWilliam Fraser
Aug 13, 2008·The Journal of Experimental Medicine·Abhishek DasMala K Maini
Sep 19, 2015·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Gabriele SacconeVincenzo Berghella
Jun 27, 2015·Liver International : Official Journal of the International Association for the Study of the Liver·Hannes HagströmKnut Stokkeland
Jun 3, 2015·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·G SacconeP Martinelli
Mar 14, 2014·BJOG : an International Journal of Obstetrics and Gynaecology·G J HofmeyrUNKNOWN Calcium and Pre-eclampsia (CAP) Study Group
Jul 7, 2012·Paediatric and Perinatal Epidemiology·Aamer Imdad, Zulfiqar A Bhutta
Mar 4, 2015·Biotechnology Advances·Rakshit K DevappaRobert F H Dekker
Mar 12, 2015·American Journal of Obstetrics and Gynecology·Gabriele Saccone, Vincenzo Berghella
Aug 23, 2001·Medical Hypotheses·J A HerreraP López-Jaramillo
Feb 1, 2008·Biology of Reproduction·Catalin NicolaChandan Chakraborty
Oct 11, 2001·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·P López-JaramilloN Serrano
Oct 3, 2018·The Cochrane Database of Systematic Reviews·G Justus HofmeyrMaria Regina Torloni
Nov 28, 2018·The Cochrane Database of Systematic Reviews·Philippa MiddletonMaria Makrides
Aug 22, 2008·Immunological Investigations·Stephen J Renaud, Charles H Graham
Mar 3, 2015·Obstetrics and Gynecology·Gabriele Saccone, Vincenzo Berghella
Nov 30, 2019·Oxidative Medicine and Cellular Longevity·Marilene Brandão TenórioMarília Oliveira Fonseca Goulart
Feb 23, 1999·Journal of Perinatal Medicine·F A Van AsscheL Aerts
Aug 12, 2000·Journal of Enzyme Inhibition·M U JavedF Michelangeli
Feb 9, 2012·Primary Care·Jean M HarnischDavid R Harnisch

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