PMID: 8590367Jun 1, 1995Paper

Prevention of pregnancy-induced hypertension by calcium dietary supplement: a preliminary report

The Journal of Obstetrics and Gynaecology
S TomodaA Hidaka

Abstract

The purpose of this study is to clarify whether the taking of a calcium dietary supplement is able to prevent the development of pregnancy-induced hypertension (PIH) in Japanese people. Forty-five nulliparous women (Ca-group) with various high-risk factors for PIH started to take a calcium supplement (1 g/day in the form of calcium salts) from the 12th gestational week (GW). Obstetrical outcome of Ca-group was compared to that of the nullipara (n = 453) who did not take a calcium supplement during pregnancy (Non-Ca Group) and that of the nullipara (n = 413) who did not develop PIH among Non-Ca group (normotensive group). The incidence of PIH in the Ca-group was 2.2%, compared to 8.8% of Non-Ca group. The decrease in blood pressure after taking calcium during the first half of the pregnancy was much greater in Ca-group than in the normotensive group. The urinary excretion of sodium and calcium and serum free calcium at the 28th GW were much lower in a woman with PIH, despite of the taking of a calcium supplement, than in the normotensive calcium group. Also, the parathyroid hormone level at the 28th GW was higher in the calcium-taking woman with PIH than in the normotensive calcium group. Our preliminary study suggests that amon...Continue Reading

References

Jul 15, 1976·American Journal of Obstetrics and Gynecology·E W Page, R Christianson
Oct 1, 1990·American Journal of Obstetrics and Gynecology·J Villar, J T Repke
Jan 1, 1986·Annual Review of Nutrition·N Karanja, D A McCarron
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