Prevention of pruritus with ethyl-chloride in skin prick test: a double-blind placebo-controlled prospective study

Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology
Amir Gal-OzGil Chernin

Abstract

Ethyl-chloride (EC) spray was recently shown to be an effective antipruritic agent, when given 15 min after histamine skin-prick test (SPT), without changing the wheal and flare reaction. We aimed to investigate the antipruritic effect of EC on SPT, when given prior to SPT. A double-blind placebo-controlled prospective study. Overall, 44 volunteers underwent histamine SPT on both arms to trigger local pruritus. Prior to test, they were randomly treated with EC spray on one arm and saline spray (placebo) on the other. Subjects as well as researchers were blinded to the type of applied sprays. The wheal and flare reaction was measured after the SPT and subjects reported the intensity of pruritus following EC/placebo using a validated pruritus questionnaire (indexes 1-3) and a visual analog scale (VAS). Significant improvement in pruritus was reported following treatment with EC compared with placebo for all four studied parameters. Index 1 in EC 3.7 ± 2.3 versus 5 ± 3.5 (p = 0.007) in placebo, index 2 in EC 2.6 ± 2.1 versus 3.8 ± 2.8 (p = 0.002) in placebo, index 3 of EC 6.3 ± 3.8 versus 8.8 ± 5.8 (p = 0.03) and VAS in EC 3.7 ± 1.9 versus 4.4 ± 2.3 (p = 0.003). There were no significant differences between EC and placebo in terms...Continue Reading

References

May 30, 1992·Lancet·F E SimonsK J Simons
Nov 1, 1989·Contact Dermatitis·W Aberer, E Zonzits
Oct 1, 1988·The British Journal of Dermatology·D ShuttleworthD M Connelly
Jan 1, 1997·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·S H Sicherer, P A Eggleston
Jun 20, 1998·Contact Dermatitis·N KriechbaumerR Jarisch
Dec 1, 2000·Progress in Brain Research·B BrommC Vahle-Hinz
Aug 15, 2001·Acta Dermato-venereologica·G YosipovitchM David
Nov 12, 2003·Archives of Pediatrics & Adolescent Medicine·Evelyn Cohen ReisRichard Holubkov
Sep 3, 2005·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Kirk H Waibel, Rohit K Katial
Jun 19, 2007·Pediatric Emergency Care·Ali Soueid, Bruce Richard
Jul 9, 2008·Current Allergy and Asthma Reports·Gil Yosipovitch, Alexandru D P Papoiu
Nov 26, 2010·Dermatology : International Journal for Clinical and Investigative Dermatology·Amir Gal-OzShmuel Kivity
Jul 20, 2011·Seminars in Cutaneous Medicine and Surgery·Akihiko IkomaMartin Steinhoff
Aug 2, 2013·Biological & Pharmaceutical Bulletin·Akihiko Ikoma

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