PMID: 9524624Apr 3, 1998Paper

Prevention of radiochemotherapy-induced mucositis. Value of the prophylactic mouth rinsing with PVP-iodine solution

Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]
Irenaus A AdamietzW Fleischer

Abstract

Oral mucositis is a frequent complication of radiochemotherapy. The origin of radiation-induced mucosa lesions is of iatrogenic nature although further development of mucositis is essentially influenced by infection. It can be assumed that disinfection measures should decrease the severity of mucositis induced by radiochemotherapy. Therefore, in a prospective randomised study the efficacy of prophylactic oral rinsing with a disinfection agent was investigated. An open, randomised, prospective comparative trial was conducted with 40 patients undergoing radiochemotherapy of head and neck region due to malignant disease. The treatment scheme consisted of irradiation to tumor region and adjacent lymph nodes with a total dose of 71.3 Gy and simultaneous chemotherapy with carboplatin (60 mg/m2) on days 1 to 5 and 29 to 34. In all patients, a prophylaxis of mucositis with nystatine, rutosides, panthenol and immunoglobulin was undertaken. In addition, 20 patients rinsed oral cavity 4 times daily with povidone-iodine-solution, the comparative group rinsed with sterile water. Clinical examination of the oral mucosa was performed weekly. Onset, grading and duration of mucositis were used as main variables. Clinically manifested oral mucos...Continue Reading

References

Sep 1, 1978·The Journal of the American Dental Association·S T SonisA Lieberman
Feb 1, 1977·Postgraduate Medicine·S DreizenL R Brown
Oct 1, 1975·American Journal of Surgery·H J WaneboH Oettgen
Aug 1, 1990·International Journal of Radiation Oncology, Biology, Physics·E Van der SchuerenE Van Limbergen
Jan 14, 1989·Lancet·A S AbdelaalM M Fergusson
Mar 1, 1989·Journal of Pain and Symptom Management·F De ConnoV Ventafridda
Jun 1, 1989·International Journal of Radiation Oncology, Biology, Physics·J B EpsteinJ J Spinelli
Mar 1, 1989·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·F K SpijkervetD M Mehta
Feb 1, 1986·The Surgical Clinics of North America·D L Larson
May 1, 1986·Archives of Otolaryngology--head & Neck Surgery·H C PillsburyJ Rosenman
Sep 14, 1984·Deutsche medizinische Wochenschrift·B GlöbelC Andres
Apr 1, 1983·The Journal of Prosthetic Dentistry·R L Engelmeier, G E King
Nov 1, 1981·Journal of Medical Microbiology·M V MartinP A Bramley
Nov 1, 1995·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·W DörrU Eckelt
Apr 1, 1997·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·W DörrT Herrmann
May 1, 1997·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·C BelkaM Barnberg

❮ Previous
Next ❯

Citations

Jun 12, 2003·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·A VissinkR P Coppes
Apr 15, 2011·The Cochrane Database of Systematic Reviews·Helen V WorthingtonTasneem Khalid
Nov 11, 2011·International Journal of Oral and Maxillofacial Surgery·A Rodríguez-CaballeroJ L Gutiérrez-Pérez

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer
Irenaus A AdamietzW Fleischer
Dermatology : International Journal for Clinical and Investigative Dermatology
R RahnW Fleischer
© 2022 Meta ULC. All rights reserved