PMID: 2491999Jan 1, 1989Paper

Prevention of recurrent diabetes in BB rats after islet transplantation by monoclonal antibody therapy

Diabetes
J F MarkmannA Naji

Abstract

Two immune responses imperil pancreatic islet allografts transplanted into subjects afflicted with autoimmune diabetes: 1) the well-described allograft response that is mounted against tissues bearing foreign transplantation antigens and 2) a recurrence of the beta-cell-specific autoimmune process responsible for the primary disease. To define the role of autoimmune response to transplanted islets, the possibility of a rejection response must be prevented. To accomplish this in spontaneously diabetic BB rats, we induced neonatal tolerance. We found that recurrent autoimmunity in tolerant BB rats can be prevented by treatment of recipients with the monoclonal antibody OX8 (specific for cytotoxic T-lymphocytes) but not W3/25 (specific for helper T-lymphocytes). These findings provide direct evidence for the role of OX8-bearing lymphocytes in autoimmune diabetogenesis.

Citations

Jun 1, 1997·Transplantation Proceedings·J Kasten-JollyB M Freed
Jan 1, 1993·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·K B YderstraedeC F Gotfredsen
Jan 26, 2006·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Michal Pearl-YafeNadir Askenasy
Jun 1, 1992·The Journal of Surgical Research·M S ShachnerC F Barker

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