Abstract
To determine whether intranasal triamcinolone acetonide prevents the regrowth of nasal polyps after polyp surgery. Randomised, double-blind, placebo-controlled, prospective study. Helsinki University Central Hospital. Sixty patients with nasal polyps entered the study. Patients were included upon arrival for elective polyp operations determined according to our standard clinical criteria. The recurrence of nasal polyposis was followed up for 9 months after surgical treatment at 3-month intervals. Anterior rhinoscopy, nasal endoscopy, olfactory threshold measurement, active anterior rhinomanometry and acoustic rhinometry were performed at every follow-up visit. On the whole, there was a significant inter-group difference in the change in polyp size of acetylsalicylic acid (ASA)-tolerant patients during the follow-up. In patients with acetylsalicylic acid intolerance, there was no inter-group difference (P = 0.28). No significant differences were noted for nasal resistance, nasal cavity volume, sense of smell and nasal symptoms. Triamcinolone acetonide prevents regrowth of nasal polyps after polyp surgery in acetylsalicylic acid-tolerant patients, but not in acetylsalicylic acid-intolerant patients.
References
Feb 1, 1996·The Journal of Allergy and Clinical Immunology·P U KnutssonP Stierna
May 30, 1998·Archives of Otolaryngology--head & Neck Surgery·V J LundD H Richards
Jul 8, 1998·American Journal of Rhinology·M TosT Tvermosegaard
Oct 13, 2000·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·S I VentoC H Malmberg
Sep 7, 2004·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M D DijkstraW J Fokkens
Feb 24, 2006·Archives of Otolaryngology--head & Neck Surgery·Pär StjärneMelvyn Danzig
Nov 1, 2006·The European Respiratory Journal·H DerendorfW Wurst
Sep 11, 2008·Allergy·H Derendorf, E O Meltzer
Oct 23, 2008·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·David P SkonerWilliam J Doyle
Jun 1, 2010·The Laryngoscope·David W J Côté, Erin D Wright
Citations
May 29, 2013·American Journal of Rhinology & Allergy·Kornkiat SnidvongsRichard J Harvey
Oct 15, 2013·American Journal of Rhinology & Allergy·Marcela FandiñoIan J Witterick
Aug 28, 2013·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Péter CsomorTamás Karosi
Feb 20, 2016·International Forum of Allergy & Rhinology·Richard R OrlandiDavid W Kennedy
Dec 17, 2014·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Cheng ZhongXueyuan Zhang
Jul 6, 2014·Clinical Otolaryngology : Official Journal of ENT-UK ; Official Journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery·S I VentoM Hytönen
Nov 9, 2016·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Shaoyan FengHuabin Li
Apr 27, 2016·The Cochrane Database of Systematic Reviews·Lee Yee ChongMartin J Burton
Apr 26, 2016·The Cochrane Database of Systematic Reviews·Larry KalishRichard J Harvey
Nov 26, 2020·International Forum of Allergy & Rhinology·Richard R OrlandiBing Zhou
Mar 19, 2021·Journal of Otolaryngology - Head & Neck Surgery = Le Journal D'oto-rhino-laryngologie Et De Chirurgie Cervico-faciale·James FowlerLeigh J Sowerby
Sep 25, 2021·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Reza SamareiFatemeh Mehdikhani
Oct 24, 2021·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Larry BorishJonathan A Bernstein