PMID: 8957364Dec 1, 1996Paper

Prevention of reperfusion injury by inhaled nitric oxide in lungs harvested from non-heart-beating donors. Paris-Sud University Lung Transplantation Group

The Annals of Thoracic Surgery
S MurakamiG M Mazmanian

Abstract

In lung transplantation using non-heart-beating donors (NHBD), the postmortem period of warm ischemia exacerbates lung ischemia-reperfusion injury. We hypothesized that inhaled nitric oxide (NO) would reduce ischemia-reperfusion injury, and thus ameliorate the viability of the lung graft. A blood-perfused, isolated rat lung model was used. Lungs were flushed and harvested from non-heart-beating donors after 30 minutes of in situ warm ischemia. The lung was then stored for 2 hours at 4 degrees C. Inhaled NO at 30 ppm was given either during the period of warm ischemia, during reperfusion, or during both periods. Lung ischemia-reperfusion injury was assessed after 1 hour of reperfusion by measuring pulmonary vascular resistance, coefficient of filtration, wet-to-dry lung weight ratio, and myeloperoxidase activity. A severe IR injury occurred in lungs undergoing ischemia and reperfusion without NO as evidenced by high values of pulmonary vascular resistance (6.83 +/- 0.36 mm Hg. mL-1.min-1), coefficient of filtration (3.02 +/- 0.35 mL.min-1.cm H2O-1 x 100 g-1), and wet-to-dry lung weight ratio (8.07 +/- 0.45). Lower values (respectively, 3.31 +/- 0.44 mm Hg.mL-1.min-1, 1.49 +/- 0.34 mL.min-1.cm H2O-1 x 100 g-1, and 7.44 +/- 0.43) ...Continue Reading

References

Nov 11, 1991·The Annals of Thoracic Surgery·T M EganB R Wilcox
Dec 6, 1994·Proceedings of the National Academy of Sciences of the United States of America·D J PinskyD M Stern
Sep 1, 1995·The Journal of Thoracic and Cardiovascular Surgery·P MacdonaldP Spratt
Aug 1, 1994·American Journal of Respiratory and Critical Care Medicine·J ReignierP Hervé
Nov 1, 1993·Circulation·J P Cooke, P S Tsao
May 1, 1993·The Annals of Thoracic Surgery·K S UlicnyB R Wilcox
Jun 1, 1993·The Annals of Thoracic Surgery·T M EganB R Wilcox
May 1, 1993·Journal of Vascular Research·K L DavenpeckA M Lefer
Nov 1, 1995·The Annals of Thoracic Surgery·M J EppingerG M Deeb

❮ Previous
Next ❯

Citations

Oct 24, 1998·The Japanese Journal of Thoracic and Cardiovascular Surgery : Official Publication of the Japanese Association for Thoracic Surgery = Nihon Kyōbu Geka Gakkai Zasshi·S TakashimaN Shimizu
Jan 6, 2001·The Japanese Journal of Thoracic and Cardiovascular Surgery : Official Publication of the Japanese Association for Thoracic Surgery = Nihon Kyōbu Geka Gakkai Zasshi·K UedaN Shimizu
Mar 29, 2001·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·S KlinzingU Klein
Dec 20, 2000·Transplantation Proceedings·I TakeyoshiY Morishita
Aug 15, 2001·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·A FehrenbachT Wahlers
Feb 9, 2002·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Shi Ping LuhPan Chyr Yang
Mar 7, 2000·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·I TakeyoshiY Morishita
Mar 14, 2000·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Y SunoseY Morishita
Mar 3, 1998·Journal of the American College of Surgeons·L P Faber
May 1, 1998·American Journal of Respiratory and Critical Care Medicine·E FadelP Dartevelle
Oct 6, 1999·American Journal of Respiratory and Critical Care Medicine·G HermleF Grimminger
May 29, 2003·American Journal of Respiratory and Critical Care Medicine·Maureen O MeadeUNKNOWN Toronto Lung Transplant Program
Aug 19, 2008·Seminars in Thoracic and Cardiovascular Surgery·Yvette M CarterDaniel Kreisel
Nov 28, 2000·The Annals of Thoracic Surgery·S TakashimaN Shimizu
Jul 23, 1998·Chest·J D ChristieR M Kotloff
Oct 16, 1999·Anesthesiology·W SteudelW M Zapol
Aug 25, 2000·American Journal of Physiology. Lung Cellular and Molecular Physiology·H SchütteF Grimminger

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.