PMID: 8967882Dec 1, 1995Paper

Prevention of restenosis after coronary angioplasty with low-density lipoprotein apheresis

Artificial Organs
H AdachiT Shinoda

Abstract

A prospective study was performed to determine whether low-density lipoprotein (LDL) apheresis, when performed only immediately before and after percutaneous transluminal coronary angioplasty (PTCA), is effective in preventing restenosis of coronary artery lesions following PTCA. Thirty-six patients with coronary heart disease (CHD) and hypercholesterolemia were divided into 2 groups. The 9 patients in the LDL group underwent LDL-apheresis 1 day before and 5 days after PTCA while the 27 patients of the control group underwent PTCA but did not undergo LDL-apheresis. Follow-up coronary angiography (CAG) was performed 4 months after PTCA. The rate of restenosis of coronary artery lesions was significantly lower in the LDL group (0%) than in the control group (30%). These findings suggest that LDL-apheresis, when performed before and after PTCA, is effective in preventing restenosis of coronary artery lesions in patients with CHD and hypercholesterolemia.

References

Jul 31, 1987·The American Journal of Cardiology·P Guiteras ValJ Lespérance
Jan 1, 1994·Chemistry and Physics of Lipids·S KanemitsuE Murakami
Sep 1, 1993·The Annals of Thoracic Surgery·T TakahashiH Matsuda

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Citations

Mar 6, 2003·Atherosclerosis·Gilbert R Thompson
Nov 29, 2001·Therapeutic Apheresis : Official Journal of the International Society for Apheresis and the Japanese Society for Apheresis·T MiyamotoT Sinoda
Mar 12, 2003·Critical Reviews in Clinical Laboratory Sciences·Giuseppe Lippi, Giancesare Guidi
Oct 19, 2001·Mayo Clinic Proceedings·A VellaT O'Brien
Dec 7, 2007·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Daniela Onofrillo, Patrizia Accorsi
Apr 29, 1998·The American Journal of Cardiology·A J LanskyM B Leon

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