Prevention of spontaneous tumors of aged mice by immunopharmacologic manipulation: study of immune antitumor mechanisms

Journal of the National Cancer Institute
M Bruley-RossetG Mathé

Abstract

Effects produced by long-term application of three immune modifiers (azimexon, retinoic acid, and tuftsin) on the depressed immune systems of 18-month-old inbred C57BL/6 female mice were investigated. The effect of each agent was examined on four cell types (cytotoxic T-cells, K-cells, NK cells, and macrophages) possibly involved in antitumor defenses and on the spontaneous tumor development that accompanied advancing age. Three substances chosen for this study appeared able to alter immune parameters, and each one displayed its own pattern of activity. Common to all three agents were an increase of age-depressed tumoricidal activity of peritoneal macrophages and no effect on the depressed NK activity of spleen cells. Retinoic acid increased splenic K-cell activity, already elevated in aged mice and unaffected by the other two agents. Cytotoxic T-cell activity, diminished by age, was stimulated considerably by retinoic acid and by tuftsin but only slightly by azimexon. Histopathologic studies revealed a decrease in the incidence of spontaneous tumors in the 3 treated groups. This decrease was statistically significant in the retinoic acid- and tuftsin-treated groups when compared with the incidence in untreated mice of the same...Continue Reading

Citations

Jan 1, 1989·Critical Reviews in Biochemistry and Molecular Biology·M Fridkin, V A Najjar
Jan 1, 1983·Annals of the New York Academy of Sciences·M K ChaudhuriV A Najjar
Jan 1, 1983·Annals of the New York Academy of Sciences·J Martinez, F Winternitz
Jan 1, 1989·Nutrition Research Reviews·A Tomkins, G Hussey
Jan 1, 1983·Annals of the New York Academy of Sciences·K NishiokaA A Amoscato
Mar 15, 1983·International Journal of Cancer. Journal International Du Cancer·M Bruley-Rosset, H Rappaport
Jul 1, 1983·International Journal of Peptide and Protein Research·J MartinezF Winternitz
Jan 4, 1988·FEBS Letters·N J Bump, V A Najjar
Jan 1, 1983·Annals of the New York Academy of Sciences·V A Najjar
Jan 1, 1983·Annals of the New York Academy of Sciences·I FlorentinG Mathé

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