PMID: 2046107Jun 26, 1991Paper

Prevention of stroke by antihypertensive drug treatment in older persons with isolated systolic hypertension. Final results of the Systolic Hypertension in the Elderly Program (SHEP). SHEP Cooperative Research Group

JAMA : the Journal of the American Medical Association


To assess the ability of antihypertensive drug treatment to reduce the risk of nonfatal and fatal (total) stroke in isolated systolic hypertension. Multicenter, randomized, double-blind, placebo-controlled. Community-based ambulatory population in tertiary care centers. 4736 persons (1.06%) from 447,921 screenees aged 60 years and above were randomized (2365 to active treatment, 2371 to placebo). Systolic blood pressure ranged from 160 to 219 mm Hg and diastolic blood pressure was less than 90 mm Hg. Of the participants, 3161 were not receiving antihypertensive medication at initial contact, and 1575 were. The average systolic blood pressure was 170 mm Hg; average diastolic blood pressure, 77 mm Hg. The mean age was 72 years, 57% were women, and 14% were black. --Participants were stratified by clinical center and by antihypertensive medication status at initial contact. For step 1 of the trial, dose 1 was chlorthalidone, 12.5 mg/d, or matching placebo; dose 2 was 25 mg/d. For step 2, dose 1 was atenolol, 25 mg/d, or matching placebo; dose 2 was 50 mg/d. Primary. Nonfatal and fatal (total) stroke. Secondary. Cardiovascular and coronary morbidity and mortality, all-cause mortality, and quality of life measures. Average follow-up...Continue Reading


Jan 18, 2014·High Blood Pressure & Cardiovascular Prevention : the Official Journal of the Italian Society of Hypertension·Stefano OmboniMassimo Volpe
Dec 29, 2000·Aging : Clinical and Experimental Research·M Barbagallo, G Barbagallo Sangiorgi
Feb 16, 2000·Lancet·M H Alderman
Feb 11, 1998·Lancet·L Green
Jun 17, 2000·European Journal of Heart Failure·S ThackrayJ G Cleland
Jul 17, 2010·Aging Clinical and Experimental Research·Richard W Besdine, Terrie Fox Wetle
Jul 16, 2005·Advances in Therapy·Jacques de Champlain
May 23, 2012·Advances in Therapy·Alejandro de la Sierra, Vivencio Barrios
Jun 19, 2001·Aging : Clinical and Experimental Research·A ScuteriJ L Fleg
Dec 25, 2013·Clínica e investigación en arteriosclerosis : publicación oficial de la Sociedad Española de Arteriosclerosis·Patricio López-JaramilloUNKNOWN nombre del Grupo de Expertos de Latinoamérica
May 13, 2014·Journal of the American Medical Directors Association·Angela Sanford, John E Morley
May 15, 2008·Archives of Cardiovascular Diseases·E Duron, O Hanon
Mar 30, 2000·Aging : Clinical and Experimental Research·A Di IorioG Abate
Jun 7, 2014·Current Hypertension Reports·Nora FranceschiniDonna K Arnett
Jun 28, 2014·Current Hypertension Reports·David Parra, Augustus Hough
Aug 6, 2005·European Journal of Clinical Pharmacology·Elisabetta PoluzziNicola Montanaro
Dec 1, 1992·Cardiovascular Drugs and Therapy·A AmeryP W de Leeuw
Nov 27, 2008·The Consultant Pharmacist : the Journal of the American Society of Consultant Pharmacists·Annie Y Lam
Jun 11, 2010·The Consultant Pharmacist : the Journal of the American Society of Consultant Pharmacists·Neetha Kamath, Kimberly A Cappuzzo
May 8, 2013·The Consultant Pharmacist : the Journal of the American Society of Consultant Pharmacists·Arthur D Strunk, Sallie D Mayer
Jun 28, 2014·Annales de cardiologie et d'angéiologie·O Hanon
Sep 13, 2014·Drugs & Aging·Martinson K ArnanCheryl Bushnell
Aug 17, 2014·Journal of General Internal Medicine·Karen L MargolisAnn V Schwartz
Jul 13, 2011·International Journal of Hypertension·F M TedlaC Brown
May 24, 2014·Current Hypertension Reports·Solomon Aronson
Nov 3, 2011·International Journal of Hypertension·Petra J Mateos-CáceresAntonio J López-Farré
Nov 19, 2014·Journal of the American Medical Directors Association·Barbara J Messinger-RapportJohn E Morley
Aug 19, 2007·Journal of Preventive Medicine and Public Health = Yebang Ŭihakhoe Chi·Jin-Young JeongDong-Hyun Kim
Sep 4, 2014·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Hong-Mo ShihLeng-Chieh Lin
Sep 29, 2011·International Journal of Hypertension·Alberto MazzaEdoardo Casiglia
Dec 17, 2008·Women's Health·Rekha Mankad, Patricia J M Best
Feb 15, 2005·Clinical Cornerstone·Maria L Soto-GreeneRobert C Like
Sep 17, 2013·Revue neurologique·S Debette
Dec 23, 1998·Journal of Women's Health·W S Aronow
Apr 10, 2010·Journal of Women's Health·Charlotta LjungmanKarin Manhem

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.