Prevention of the cardiovascular and renal effects of angiotensin II by endothelin blockade

Hypertension
A HeriziA Mimran

Abstract

Angiotensin II (Ang II) stimulates the release and gene expression of endothelin-1 in isolated vascular smooth muscle cells. In 47 Sprague-Dawley rats, we assessed the influence of concomitant treatment by the mixed ET(A)/ET(B) endothelin receptor antagonist bosentan (30 mg/kg per day, gavage) on the effect of a 10-day infusion of Ang II (200 ng/kg per minute, SC, osmotic pump) on arterial pressure, renal hemodynamics (microsphere method), albuminuria, cardiac weight, and carotid structure. Ang II increased systolic arterial pressure (SAP) by 49+/-7 mm Hg. Although bosentan alone did not affect SAP, the development of Ang II-induced hypertension was entirely prevented by the endothelin antagonist. In addition, the reduction in renal blood flow induced by Ang II (4.9+/-0.3 versus 7.4+/-0.2 mL x min-1 x g-1 in control rats) was prevented by concomitant administration of bosentan (8.8+/-0.8 mL x min-1 x g-1). The marked increase in albuminuria observed in rats infused with Ang II (2524+/-961 versus 91+/-6 microg/24 h in control rats) was prevented by bosentan. Similarly, bosentan abolished the increase in heart weight index (from 2.96+/-0.03 to 3.41+/-0.08 mg/g body weight) and carotid media thickness (from 73+/-14 to 108+/-6 micr...Continue Reading

References

May 1, 1992·Hypertension·R J JohnsonS M Schwartz
Jun 1, 1990·Physiology & Behavior·M J FreglyN E Rowland
Feb 15, 1987·The American Journal of Cardiology·M S ZimblerJ H Laragh
Apr 1, 1993·The Journal of Clinical Investigation·Y HirataF Marumo

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Citations

Apr 8, 2006·Current Hypertension Reports·Gabriel VorobiofJohn D Bisognano
Sep 12, 2000·Current Hypertension Reports·P Moreau, T J Rabelink
Sep 25, 2003·Metabolism: Clinical and Experimental·Norman L M WongJoseph K C Tsui
Mar 21, 2002·Clinical and Experimental Pharmacology & Physiology·S FicaiB Jover
Apr 19, 2003·Clinical and Experimental Pharmacology & Physiology·H R De SmetP A Phillips
Jun 3, 2000·Journal of Cardiovascular Pharmacology·S E BurkeB F Cox
Mar 21, 2002·Journal of Cardiovascular Pharmacology·Alessandro CosenziG Bellini
Jun 27, 2003·Journal of Cardiovascular Pharmacology·Shuang-Shuang DingMartine Clozel
Dec 14, 1999·Current Opinion in Nephrology and Hypertension·M Barton, T F Luscher
Apr 11, 2000·Current Opinion in Nephrology and Hypertension·D M Pollock
Apr 5, 2013·Clinical and Experimental Pharmacology & Physiology·Duncan J Campbell
Sep 22, 2005·Clinical and Experimental Pharmacology & Physiology·Wen-Sen LeePaul Chan
Jan 21, 2011·Physiological Reviews·Donald E KohanDavid M Pollock
Jun 23, 2001·Drugs & Aging·M P Love, J J McMurray
Jul 4, 2003·Canadian Journal of Physiology and Pharmacology·Pierre Moreau, Ernesto L Schiffrin
Aug 21, 2010·Canadian Journal of Physiology and Pharmacology·Erika I BoesenDavid M Pollock
Sep 8, 2000·Journal of Cardiovascular Pharmacology·F S Zollmann, M Paul
Sep 19, 2009·Heart Failure Reviews·Navneet S Rehsia, Naranjan S Dhalla
Aug 5, 1998·Current Opinion in Nephrology and Hypertension·L Rothermund, M Paul
Jan 5, 2001·Expert Opinion on Investigational Drugs·P Moreau, H H Dao
Jan 5, 2002·Expert Opinion on Investigational Drugs·P Moreau, H H Dao
Oct 27, 2004·Expert Opinion on Investigational Drugs·Ariela BenigniGiuseppe Remuzzi
Aug 25, 2006·Renal Failure·Anastasios DrakopoulosSotiris Tsakas
Sep 24, 2011·International Journal of Inflammation·Norifumi Takeda, Ichiro Manabe
Jan 18, 2006·British Journal of Pharmacology·Adelino F Leite-MoreiraJoão Ferreira-Martins
Feb 3, 2005·Free Radical Biology & Medicine·Marc-André LaplanteJacques de Champlain
Oct 25, 2002·Journal of Cardiac Failure·Maria A CavasinXiao-Ping Yang
Jul 18, 2006·European Journal of Pharmacology·Paulo Castro-ChavesAdelino F Leite-Moreira
Jan 19, 2012·Renal Failure·Claudete Maria ZanattaLuis Henrique Canani
Jun 13, 2001·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·H K ParkW J Lee

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