Prevention of the exposure by cyclophosphamide oral tablet

Journal of Pharmaceutical Health Care and Sciences
Takae HanadaTakashi Egawa

Abstract

Unintended exposure to antitumor agents from an oral medicine may place healthcare workers and patients taking medicine at risk. In this study, the exposure to blister pack by CP (cyclophosphamide) and appropriate preventive procedures were examined. CP detected inside the blister pack of the tested seven lots by LC-MS/MS ranged from 8.2 to 199.6 ng. Raman imaging clearly showed that CP ingredient was completely covered by the tablet coating layer and had not leached out of the tablet. In addition, the amount of CP detected inside the vials was suppressed under the lower detection limit until day 28, and only 6.0 ng was detected only at day 56. Various amounts of CP were contaminated to not only the inside of the blister pack but also the outside. This contamination may be caused not only by the manufacturing environment but also by the CP oral tablets themselves through volatilization of CP. Refrigerated storage of CP oral tablets may protect healthcare workers and patients from contact with CP.

References

Jan 1, 1997·International Archives of Occupational and Environmental Health·O Nygren, C Lundgren
Nov 7, 2003·The Annals of Occupational Hygiene·H J MasonK Jones
Mar 5, 2005·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Thomas H ConnorRobert Dechristoforo
Dec 11, 2007·International Archives of Occupational and Environmental Health·M HedmerB A G Jönsson
Jan 15, 2014·The Annals of Occupational Hygiene·Wouter FransmanBas J Blaauboer

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