Prevention of the progression of renal injury in diabetic rodent models with preexisting renal disease with chronic endothelin A receptor blockade.

American Journal of Physiology. Renal Physiology
Denisha SpiresJan M Williams

Abstract

The endothelin (ET) system has emerged as a therapeutic target for the treatment of diabetic nephropathy (DN). The present study examined whether chronic endothelin A (ETA) receptor blockade with atrasentan prevents the progression of renal injury in two models of DN with preexisting renal disease that exhibit an increased renal ET-1 system compared with nondiabetic rats: streptozotocin-treated Dahl salt-sensitive (STZ-SS) and type 2 diabetic nephropathy (T2DN) rats. Nine week-old SS rats were treated with (STZ; 50 mg/kg ip) to induce diabetes. After 3 wk of diabetes, proteinuria increased to 353 ± 34 mg/day. The rats were then separated into two groups: 1) vehicle and 2) atrasentan (5 mg·kg-1·day-1) via drinking water. After 6 wk of treatment with atrasentan, mean arterial pressure (MAP) and proteinuria decreased by 12 and 40%, respectively, in STZ-SS rats. The degree of glomerulosclerosis and renal fibrosis was significantly reduced in the kidneys of atrasentan-treated STZ-SS rats compared with vehicle STZ-SS rats. Interestingly, treatment with atrasentan did not affect GFR but significantly increased renal blood flow by 33% and prevented the elevations in filtration fraction and renal vascular resistance by 23 and 20%, respe...Continue Reading

References

Jan 14, 1999·The American Journal of Physiology·R P Van DokkumR J Roman
Mar 10, 1999·The American Journal of Physiology·R P van DokkumR J Roman
Sep 30, 2000·Kidney International·G M HargroveN C Wong
Nov 6, 2003·Physiological Genomics·David L MattsonAllen W Cowley
Feb 28, 2004·Diabetes·Marcelo A NobregaHoward J Jacob
Mar 9, 2005·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Jean-Claude AnsquerUNKNOWN DAIS Investigators
Oct 19, 2005·British Journal of Pharmacology·Edward W InschoDavid M Pollock
Nov 24, 2005·American Journal of Physiology. Renal Physiology·Bernardo LópezRichard J Roman
Jan 7, 2006·American Journal of Physiology. Renal Physiology·Richard J RomanAlbert Sarkis
Dec 15, 2006·Journal of the American Society of Nephrology : JASN·Jennifer M SasserJennifer S Pollock
Jul 26, 2008·American Journal of Physiology. Renal Physiology·David L MattsonAllen W Cowley
Oct 10, 2008·American Journal of Physiology. Renal Physiology·Jan Michael WilliamsRichard J Roman
Apr 2, 2009·European Journal of Clinical Investigation·W Neuhofer, D Pittrow
Jan 7, 2010·Current Opinion in Nephrology and Hypertension·Donald E Kohan
Jan 25, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Carol MorenoRichard J Roman
Mar 5, 2011·Journal of the American Society of Nephrology : JASN·Donald E KohanDennis L Andress
Apr 8, 2011·The Journal of Pharmacology and Experimental Therapeutics·Mohamed A SalehDavid M Pollock
Sep 7, 2011·Contributions to Nephrology·Matthias Barton, Donald E Kohan
Mar 24, 2012·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Jan M WilliamsRichard J Roman
Mar 16, 2013·The Journal of Pharmacology and Experimental Therapeutics·Naoki KojimaRichard J Roman
Aug 9, 2013·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Tiffani N SlaughterJan M Williams
Dec 10, 2013·Journal of Diabetes & Metabolism·Naoki KojimaJan M Williams
May 9, 2014·Kidney International·Donald E Kohan, Matthias Barton
Sep 6, 2014·The Journal of Pharmacology and Experimental Therapeutics·Chunhua JinDavid M Pollock
Jul 15, 2015·Physiological Reports·Naoki KojimaRichard J Roman
Aug 5, 2015·Journal of Clinical Medicine·Lidia AnguianoMaría José Soler
Sep 29, 2017·Cardiovascular Drugs and Therapy·Corey MageeDerek P Brazil

❮ Previous
Next ❯

Citations

Nov 5, 2019·Hypertension·Matthias Barton, Masashi Yanagisawa
Feb 16, 2020·Nature Reviews. Nephrology·Marta Ruiz-OrtegaRaul R Rodrigues-Diez
Apr 9, 2020·Diabetes, Obesity & Metabolism·Jonatan Barrera-Chimal, Frédéric Jaisser
May 12, 2020·American Journal of Physiology. Renal Physiology·Bibek PoudelJan M Williams
Oct 1, 2019·American Journal of Physiology. Renal Physiology·Oleg PalyginAlexander Staruschenko
Aug 18, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Tengis S PavlovAlexander Staruschenko
Mar 19, 2020·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Ariela BenigniDonald E Kohan
May 16, 2020·Drug Discovery Today·Frederikke E SembachLisbeth N Fink
Nov 4, 2020·International Journal of Molecular Sciences·Markus PirklbauerHerbert Schramek
Jun 9, 2021·Cellular and Molecular Life Sciences : CMLS·David DolivoThomas Mustoe
Apr 20, 2021·Physiological Genomics·Denisha R SpiresAlexander Staruschenko
Jun 3, 2021·International Journal of Molecular Sciences·Markus PirklbauerHerbert Schramek
Aug 7, 2021·Pflügers Archiv : European journal of physiology·Thomas H NederCharlotte Wagner

❮ Previous
Next ❯

Datasets Mentioned

BETA
GM-115428

Methods Mentioned

BETA
ELISA
protein assay
urine collection

Software Mentioned

NIS
Elements D

Related Concepts

Related Feeds

CV Disorders & Type 2 Diabetes

This feed focuses on the association of cardiovascular diseases in patients with type 2 diabetes.

Related Papers

American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
Tiffani N SlaughterJan M Williams
The Journal of Pharmacology and Experimental Therapeutics
Naoki KojimaRichard J Roman
American Journal of Physiology. Renal Physiology
Jan M WilliamsRichard J Roman
© 2022 Meta ULC. All rights reserved