Prevention of the transient adverse effects of a gonadotropin-releasing hormone analogue (buserelin) in metastatic prostatic carcinoma by administration of an antiandrogen (nilutamide)

The New England Journal of Medicine
J M KuhnR Dahan

Abstract

Gonadotropin-releasing hormone (GnRH) analogues administered for the treatment of advanced prostatic cancer induce a transient increase in plasma testosterone levels during the first week of treatment, often with a secondary rise in plasma levels of prostatic acid phosphatase and a flareup of disease. To determine whether the antiandrogen nilutamide (Anandron) blocks these effects, we carried out a multicenter, placebo-controlled study of nilutamide in men with prostatic cancer treated with the GnRH analogue buserelin. Thirty-six men with disseminated prostatic cancer and elevated plasma levels of prostatic acid phosphatase were randomly assigned to two groups. Group 1 included 17 men who received buserelin (500 micrograms daily subcutaneously) and nilutamide (300 mg daily by mouth); group 2 included 19 men treated with buserelin and placebo. Symptoms were assessed, and plasma was collected before treatment, daily for 14 days, and on days 18, 22, and 29 after the initiation of treatment. Bone pain appeared or worsened in 5 of the 17 men in group 1 and in 12 of the 19 men in group 2 (P less than 0.05). Acute urinary obstruction occurred in one man in group 2. Despite similar changes in the plasma testosterone levels in both grou...Continue Reading

References

Apr 1, 1987·The Journal of Urology·P GuinanP Ray
Oct 8, 1987·The New England Journal of Medicine·T A StameyE Redwine
Jan 1, 1987·Journal of Steroid Biochemistry·M MoguilewskyM Hucher
Feb 1, 1987·The Journal of Urology·W G Hendren, G J Monfort
Feb 1, 1984·The Journal of Clinical Endocrinology and Metabolism·R J SantenL M Glode
Nov 15, 1984·The New England Journal of Medicine·UNKNOWN Leuprolide Study Group

❮ Previous
Next ❯

Citations

Jun 1, 1993·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·A Goulding, E Gold
Aug 15, 2006·Current Treatment Options in Oncology·Abraham Morgentaler
Oct 30, 2009·Current Urology Reports·Ernani Luis Rhoden, Márcio Augusto Averbeck
Nov 1, 1994·Current Problems in Cancer·W R LeeG E Hanks
Jan 1, 1992·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·A V SchallyD Gonzalez-Barcena
Dec 20, 1990·The Journal of Steroid Biochemistry and Molecular Biology·M NamerJ P Droz
Aug 15, 2001·Urology·G J Bubley
Jun 6, 2000·Advanced Drug Delivery Reviews·M LeeR Sharifi
Jul 4, 2012·Prostate Cancer and Prostatic Diseases·N D ShoreP Lange
Jan 20, 1991·The New England Journal of Medicine·P M Conn, W F Crowley
Jan 24, 1991·The New England Journal of Medicine·R F Gittes
Oct 13, 1994·The New England Journal of Medicine·W J Catalona
Oct 8, 1998·The New England Journal of Medicine·M A EisenbergerB A Lowe
Sep 24, 2010·Endocrine-related Cancer·Nima SharifiWilliam L Dahut
Feb 6, 2014·The Journal of Steroid Biochemistry and Molecular Biology·David J HandelsmanAnn J Conway
Aug 1, 1994·Controlled Clinical Trials·D H Williams, C E Davis
Nov 1, 2007·Expert Opinion on Investigational Drugs·Andrea C WilsonCraig S Atwood
Feb 28, 2001·Expert Opinion on Investigational Drugs·K A Harris, E J Small
Jan 1, 1993·Acta Oncologica·G PrevostF Thomas
Jul 22, 2008·The Journal of Sexual Medicine·Ernani Luis RhodenPatrick E Teloken
Apr 15, 2008·Urology·Hendrik van Poppel, Sten Nilsson
Nov 7, 2007·The Urologic Clinics of North America·Abraham Morgentaler
Oct 13, 2007·International Journal of Andrology·Anne Cailleux-BounacerJean Marc Kuhn

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.