Prevention of Thromboembolic Complications After Spine Surgery by the Use of Low-Molecular-Weight Heparin

World Neurosurgery
Xiao-Jun Zeng, Hao Peng

Abstract

This study aimed to evaluate the effectiveness and safety of the use of low-molecular-weight heparin (LMWH) in the prevention of thromboembolic complications after spine surgery. We conducted a retrospective study on 2 groups of patients receiving spine surgery. A total of 947 patients admitted for surgery from July 2009 to June 2012 were administered therapeutic dose of LMWH daily after the surgery (therapeutic group). Another 814 patients enrolled from July 2006 to June 2009 were not given any heparin treatment (control group). The wound drainage volume, the incidence rate of thrombosis and thromboembolic complications, and the occurrence of bleeding complications in 2 groups were statistically compared. The therapeutic group showed a lower rate of postsurgery thromboembolic complications when compared with the control group (therapeutic group, 0.21%; control group, 1.6%; P = 0.002). Among the individual type of complications, the occurrence of cerebral infraction was the most significantly reduced (P = 0.005). The overall rate of bleeding complications was higher in the therapeutic group compared with the control group, and the difference was marginally insignificant (therapeutic group, 1.8%; control group, 0.74%; P = 0.051)...Continue Reading

References

Nov 14, 2000·Spine·T OdaN Kanemitsu
Nov 15, 2003·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Rüdiger GerlachVolker Seifert
Feb 16, 2007·The New England Journal of Medicine·Magdy Selim
May 7, 2010·Spine·Joseph S ChengJoseph R Dettori
Jan 10, 2012·Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association·Hiroshi TakahashiAkihito Wada
Feb 2, 2012·HSS Journal : the Musculoskeletal Journal of Hospital for Special Surgery·Han Jo KimGeoffrey H Westrich

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Citations

Jan 15, 2020·Global Spine Journal·Anthony M AlvaradoPaul M Arnold
Oct 10, 2020·Global Spine Journal·Samantha SolaruRaymond J Hah
Jan 15, 2021·The Spine Journal : Official Journal of the North American Spine Society·Bertrand DebonoHans D de Boer

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