PMID: 2107870Mar 1, 1990Paper

Prevention of thromboxane B2-induced hepatocyte plasma membrane bleb formation by certain prostaglandins and a proteinase inhibitor

Biochimica Et Biophysica Acta
A A Horton, J M Wood

Abstract

Isolated hepatocytes incubated in the presence of thromboxane B2 developed many plasma membrane blebs which are a characteristic feature of toxic or ischaemic cell injury. When hepatocytes were incubated in the presence of both thromboxane B2 and the non-lysosomal proteinase inhibitor, leupeptin, were also well protected from the formation of blebs. This implies that thromboxane B2 is able to activate non-lysosomal proteinases which appear to attack certain cytoskeletal proteins. The data presented are consistent with thromboxane B2 acting as an intermediary in a proposed mechanism of cell injury and death in which elevated cytosolic free Ca2+ levels activate phospholipase A2 and the arachidonic acid cascade.

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Citations

May 1, 1993·Transplant International : Official Journal of the European Society for Organ Transplantation·H H DöşlüoğluS Ercan
Jan 1, 1993·Pharmacology & Therapeutics·J Quiroga, J Prieto
Jul 3, 1998·Toxicology Letters·M H Daba, M S Abdel-Rahman
Apr 2, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Atsushi KudoMakoto Suematsu
May 23, 2012·The Journal of Surgical Research·Atsushi KudoShigeki Arii
Jan 1, 1992·Free Radical Research Communications·L ClaytonG Aber

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