PMID: 6985681Jan 18, 1980Paper

Prevention of traveler's diarrhea (emporiatric enteritis). Prophylactic administration of subsalicylate bismuth)

JAMA : the Journal of the American Medical Association
H L DuPontW S Tjoa

Abstract

The efficacy of a daily dosage regimen of subsalicylate bismuth in preventing or reducing the severity of diarrhea among young healthy adults was evaluated in a double-blind, randomized, placebo-controlled trial. Diarrhea developed in 14 (23%) of 62 students receiving subsalicylate bismuth compared with 40 (61%) of 66 students taking a placebo. The protective effect of subsalicylate bismuth was apparent within a day or two of the study onset and became more obvious as the number of days at risk increased. The students treated with subsalicylate bismuth experienced fewer intestinal complaints and were less likely to pass soft or watery stools of any number. Once diarrhea occurred, enteropathogens were less commonly identified in stools of students receiving subsalicylate bismuth (33%) compared with placebo (71%). Subsalicylate bismuth was well tolerated by students during the 21-day trial.

Citations

Apr 1, 1986·Antimicrobial Agents and Chemotherapy·R SteffenM Schär
Jul 21, 2009·Current Gastroenterology Reports·Emily Singh, David Redfield
Sep 5, 2012·Nature Reviews. Gastroenterology & Hepatology·Stacy MeneesWilliam D Chey
Jun 1, 1993·Baillière's Clinical Gastroenterology·R C Arduino, H L DuPont
Feb 21, 2002·Current Infectious Disease Reports·Allen C. Cheng, Nathan M. Thielman
Jun 10, 1993·The New England Journal of Medicine·D Figueroa-QuintanillaE Eyzaguirre-Maccan
Jan 1, 1981·Pharmacology & Therapeutics·R N Greenberg, R L Guerrant
Jan 1, 1981·Pharmacology & Therapeutics·H L DuPontT K Satterwhite
Jan 1, 1988·Journal of Drug Education·B R Carlson, J L Davis
Jun 1, 1994·Journal of Travel Medicine·H L DuPont, F M Khan
Mar 1, 1997·Journal of Travel Medicine·E HiltonM Smith
Jun 20, 1990·The American Journal of Medicine·M S Wolfe
May 12, 1988·The New England Journal of Medicine·C O TacketM M Levine
Sep 30, 1982·The New England Journal of Medicine·S L Gorbach

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