Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance

The New England Journal of Medicine
J TuomilehtoFinnish Diabetes Prevention Study Group

Abstract

Type 2 diabetes mellitus is increasingly common, primarily because of increases in the prevalence of a sedentary lifestyle and obesity. Whether type 2 diabetes can be prevented by interventions that affect the lifestyles of subjects at high risk for the disease is not known. We randomly assigned 522 middle-aged, overweight subjects (172 men and 350 women; mean age, 55 years; mean body-mass index [weight in kilograms divided by the square of the height in meters], 31) with impaired glucose tolerance to either the intervention group or the control group. Each subject in the intervention group received individualized counseling aimed at reducing weight, total intake of fat, and intake of saturated fat and increasing intake of fiber and physical activity. An oral glucose-tolerance test was performed annually; the diagnosis of diabetes was confirmed by a second test. The mean duration of follow-up was 3.2 years. The mean (+/-SD) amount of weight lost between base line and the end of year 1 was 4.2+/-5.1 kg in the intervention group and 0.8+/-3.7 kg in the control group; the net loss by the end of year 2 was 3.5+/-5.5 kg in the intervention group and 0.8+/-4.4 kg in the control group (P<0.001 for both comparisons between the groups)....Continue Reading

Associated Clinical Trials

Aug 6, 2008·Geoffrey Williams

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Citations

Apr 29, 2009·Archives of Internal Medicine·Dariush MozaffarianDavid Siscovick
May 8, 2002·Diabetes/metabolism Research and Reviews·Anne Peters Harmel
Sep 24, 2004·Diabetes/metabolism Research and Reviews·Tom L BroderickMelissa Gillis
Sep 24, 2004·Diabetes/metabolism Research and Reviews·Tracy L EllisonSimon A Moyes
Sep 24, 2004·Diabetes/metabolism Research and Reviews·Itamar RazEleazar Shafrir
Jul 1, 2004·Environmental Health and Preventive Medicine·Kaoru Hirose, Kazuo Tajima
Jun 7, 2006·Eating and Weight Disorders : EWD·F CerrelliG Marchesini
Jun 28, 2006·Eating and Weight Disorders : EWD·I MelinB Karlström
Sep 14, 2010·International Journal of Public Health·Marte Karoline Råberg KjøllesdalMargareta Wandel
Sep 14, 2011·International Journal of Public Health·Glenn Laverack
May 15, 2010·Herz·Baptist Gallwitz
Oct 12, 2005·Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz·M Burger, F Tiemann
Oct 3, 2006·Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz·H-G Joost
Jul 25, 2009·Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz·N StefanH-U Häring
Dec 14, 2006·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Peter WeyrichAndreas Fritsche
Jan 11, 2012·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Alexander BarteltJoerg Heeren
May 24, 2006·Diabetologia·I MühlhauserUNKNOWN Federation of European Nurses in Diabetes
Aug 29, 2007·Diabetologia·D E LaaksonenUNKNOWN Finnish Diabetes Prevention Study Group
Jan 9, 2009·Diabetologia·C HerderUNKNOWN Finnish Diabetes Prevention Study Group

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