Prevention of Urinary Stones With Hydration (PUSH): Design and Rationale of a Clinical Trial.

American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
Charles D ScalesUrinary Stone Disease Research Network

Abstract

Although maintaining high fluid intake is an effective low-risk intervention for the secondary prevention of urinary stone disease, many patients with stones do not increase their fluid intake. We describe the rationale and design of the Prevention of Urinary Stones With Hydration (PUSH) Study, a randomized trial of a multicomponent behavioral intervention program to increase and maintain high fluid intake. Participants are randomly assigned (1:1 ratio) to the intervention or control arm. The target sample size is 1,642 participants. Adults and adolescents 12 years and older with a symptomatic stone history and low urine volume are eligible. Exclusion criteria include infectious or monogenic causes of urinary stone disease and comorbid conditions precluding increased fluid intake. All participants receive usual care and a smart water bottle with smartphone application. Participants in the intervention arm receive a fluid intake prescription and an adaptive program of behavioral interventions, including financial incentives, structured problem solving, and other automated adherence interventions. Control arm participants receive guideline-based fluid instructions. The primary end point is recurrence of a symptomatic stone during...Continue Reading

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References

Nov 1, 1985·Journal of Occupational Medicine. : Official Publication of the Industrial Medical Association·J L ForsterM K Snell
Jul 1, 1994·Archives of General Psychiatry·S T HigginsG J Badger
Jun 1, 1996·Drug and Alcohol Dependence·K SilvermanK L Preston
Feb 11, 2003·The Journal of Urology·Joan H ParksFrederic L Coe
Jan 26, 2006·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Kevin G VolppCaryn Lerman
Aug 21, 2007·Experimental and Clinical Psychopharmacology·Ryan VandreyMaxine L Stitzer
Dec 11, 2008·JAMA : the Journal of the American Medical Association·Kevin G VolppGeorge Loewenstein
Dec 24, 2008·BMC Health Services Research·Kevin G VolppStephen E Kimmel
Feb 14, 2009·The New England Journal of Medicine·Kevin G VolppJanet Audrain-McGovern
Jan 21, 2011·Journal of General Internal Medicine·Leslie K JohnKevin G Volpp
Feb 22, 2012·The Journal of Urology·Lipika R McCauleyMike M Nguyen
Apr 14, 2012·European Urology·Charles D ScalesUNKNOWN Urologic Diseases in America Project
Aug 11, 2012·American Heart Journal·Stephen E KimmelKevin Volpp
Apr 3, 2013·Annals of Internal Medicine·Jeffrey T KullgrenKevin G Volpp
May 27, 2014·The Journal of Urology·Margaret S PearleJames R White
Aug 12, 2014·Journal of the American Society of Nephrology : JASN·Andrew D RuleEric J Bergstralh
Nov 5, 2014·Annals of Internal Medicine·Amir QaseemUNKNOWN Clinical Guidelines Committee of the American College of Physicians
May 15, 2015·The New England Journal of Medicine·Scott D HalpernKevin G Volpp
Jan 16, 2016·Clinical Journal of the American Society of Nephrology : CJASN·Gregory E TasianSusan L Furth
Mar 12, 2016·Clinical Journal of the American Society of Nephrology : CJASN·Charles D ScalesZiya Kirkali
Mar 16, 2016·Journal of General Internal Medicine·Mitesh S PatelKevin G Volpp
Feb 18, 2018·Mayo Clinic Proceedings·Wonngarm KittanamongkolchaiAndrew D Rule

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Citations

Oct 22, 2020·Journal of Endourology·Charles D ScalesJonathan D Harper
Mar 12, 2021·Nature Reviews. Urology·Jared S WinokerBrian R Matlaga

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