Prevention of UV radiation-induced premature skin aging in hairless mice by the novel compound Melanocin A

Photochemistry and Photobiology
Chi-Hyun ParkJin Ho Chung

Abstract

Repetitive exposure of the skin to UV radiation induces various harmful changes, such as thickening, wrinkle formation, inflammation and carcinogenesis. A variety of natural compounds and synthetic compounds have been studied to determine whether they can prevent UV-induced harmful effects. In this study, we investigated the effect of a novel compound, Melanocin A, which was isolated from Eupenicillium shearii F80695, on UV-induced premature skin aging. First, we studied the effect of Melanocin A on UV-induced matrix metalloproteinase (MMP)-9 expression in an immortalized human keratinocyte cell line, HaCaT, in vitro. Acute UV irradiation induced MMP-9 expression at both the mRNA and protein levels and Melanocin A suppressed this expression in a dose-dependent manner. We then investigated the effect of Melanocin A on UV-induced skin changes in hairless mice in vivo. Chronic exposure of hairless mouse dorsal skin to UV increased skin thickness and induced wrinkle formation and the gelatinase activities of MMP-2 and MMP-9. Moreover, Melanocin A significantly suppressed UV-induced morphologic skin changes and MMP-2 and MMP-9 expression. Taken together, these results show that Melanocin A can prevent the harmful effects of UV that ...Continue Reading

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Citations

Jun 16, 2009·Expert Opinion on Biological Therapy·Won-Serk KimJong-Hyuk Sung
Feb 11, 2012·Journal of Photochemistry and Photobiology. B, Biology·Byul-Nim AhnSe-Kwon Kim
May 13, 2011·The Journal of Investigative Dermatology·Eun Ju KimJin Ho Chung
Sep 4, 2010·Experimental Dermatology·Ji-Seon LeeHyuk-Jin Cha
Apr 4, 2014·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·R C S BarcelosM E Bürger
Jan 14, 2016·Korean Journal for Food Science of Animal Resources·Yooheon ParkHyung Joo Suh
Nov 9, 2011·The Journal of Pharmacy and Pharmacology·Yoshiyuki Kimura, Maho Sumiyoshi

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Methods Mentioned

BETA
PCR
electrophoresis

Software Mentioned

Excel
skin visiometer SV600

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