Prevention of vaccine-matched and mismatched influenza in children aged 6-35 months: a multinational randomised trial across five influenza seasons

The Lancet Child & Adolescent Health
Carine ClaeysFlu4VEC Study Group

Abstract

Despite the importance of vaccinating children younger than 5 years, few studies evaluating vaccine prevention of influenza have been reported in this age group. We evaluated efficacy of an inactivated quadrivalent influenza vaccine (IIV4) in children aged 6-35 months. In this phase 3, observer-blinded, multinational trial, healthy children from 13 countries in Europe, Central America, and Asia were recruited in five independent cohorts, each in a different influenza season. Participants were randomly assigned (1:1) to either IIV4 (15 μg haemagglutinin antigen per strain per 0·5 mL dose; a single dose on day 0 for vaccine-primed children, and two doses, on days 0 and 28, for vaccine-unprimed children) or to one or two doses of a non-influenza control vaccine. Primary endpoints were moderate-to-severe influenza or all influenza (irrespective of disease severity) confirmed by RT-PCR on nasal swabs. Cultured isolates were further characterised as antigenically matched or mismatched to vaccine strains. Efficacy was assessed in the per-protocol cohort and total vaccinated cohort (time-to-event analysis), and safety was assessed in the total vaccinated cohort. Between Oct 1, 2011, and Dec 31, 2014, 12 018 children were recruited into...Continue Reading

Citations

Sep 21, 2018·Human Vaccines & Immunotherapeutics·Kursat Bora CarmanEner Cagri Dinleyici
Jan 29, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Aldiouma DialloJohn C Victor
Jun 23, 2019·Expert Review of Vaccines·Justin R Ortiz, Kathleen M Neuzil
Aug 24, 2019·MMWR. Recommendations and Reports : Morbidity and Mortality Weekly Report. Recommendations and Reports·Lisa A GrohskopfDaniel B Jernigan
Feb 29, 2020·Journal of the Pediatric Infectious Diseases Society·Leora R FeldsteinAngela P Campbell
Oct 28, 2019·Human Vaccines & Immunotherapeutics·Ruprecht Schmidt-OttMartin Eichner
Feb 25, 2020·The Pediatric Infectious Disease Journal·Janna-Maija MattilaTerho Heikkinen
Nov 15, 2019·Journal of the Pediatric Infectious Diseases Society·Suchitra RaoEdwin J Asturias
Feb 5, 2019·The Journal of Infectious Diseases·Justin R Ortiz, Kathleen M Neuzil
Jul 3, 2018·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Meredith L McMorrowCheryl Cohen
Aug 25, 2018·MMWR. Recommendations and Reports : Morbidity and Mortality Weekly Report. Recommendations and Reports·Lisa A GrohskopfDaniel B Jernigan
Apr 22, 2021·The New England Journal of Medicine·Jerald SadoffUNKNOWN ENSEMBLE Study Group
Oct 14, 2021·The New England Journal of Medicine·Terence NolanJonathan M Edelman
Oct 26, 2021·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Ignacio Salamanca de la CuevaEmad Yanni
Sep 9, 2021·Pediatrics·UNKNOWN COMMITTEE ON INFECTIOUS DISEASES
Sep 4, 2019·Pediatrics·UNKNOWN COMMITTEE ON INFECTIOUS DISEASES

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.