Prevention of Vascular Inflammation by Pterostilbene via Trimethylamine-N-Oxide Reduction and Mechanism of Microbiota Regulation

Molecular Nutrition & Food Research
Yen-Chun KohMin-Hsiung Pan

Abstract

A gut-microbiota-dependent metabolite of L-carnitine, trimethylamine-N-oxide (TMAO), has been recently discovered as an independent and dose-dependent risk factor for cardiovascular disease (CVD). This study aims to investigate the effects of pterostilbene on reducing TMAO formation and on decreasing vascular inflammation in carnitine-feeding mice. C57BL/6 mice are treated with 1.3% carnitine in drinking water with or without pterostilbene supplementation. Using LC-MS/MS, the result shows that mice treated with 1.3% carnitine only significantly increased the plasma TMAO and pterostilbene supplementation group can reverse it. Additionally, pterostilbene decreases hepatic flavin monooxygenase 3 (FMO3) mRNA levels compared to carnitine only group. It appears that pterostilbene can alter host physiology and create an intestinal microenvironment favorable for certain gut microbiota. Gut microbiota analysis reveals that pterostilbene increases the abundance of Bacteroides. Further, pterostilbene decreases mRNA levels of vascular inflammatory markers tumor necrosis factor-α (TNF-α), vascular cell adhesion molecule 1 (VCAM-1), and E-selectin). These data suggest that amelioration of carnitine-induced vascular inflammation after consump...Continue Reading

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Citations

May 13, 2020·Nutrients·Christopher PapandreouAouatef Bellamine
Nov 12, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yeju LiuZhihong Yang
Feb 13, 2021·The Journal of Nutritional Biochemistry·Lisard Iglesias-CarresAndrew P Neilson
Mar 17, 2021·Critical Reviews in Food Science and Nutrition·Jie CaiYing Liang
Oct 12, 2021·Frontiers in Neurology·Vishakha SharmaVida Abedi
Sep 11, 2021·Molecular Nutrition & Food Research·Yen-Chun KohMin-Hsiung Pan
Dec 7, 2021·Frontiers in Cardiovascular Medicine·Jingfeng ChenSuying Ding

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