Oct 20, 2010

Prevention of vertical transmission of HIV-1 in resource-limited settings

Expert Review of Anti-infective Therapy
Anna CoutsoudisMairi Thomson

Abstract

One of the most exciting areas of HIV research is that of prevention of vertical transmission from mother to child, since it accounts for 90% of childhood HIV infections, and therefore prevention in this context has an enormous potential impact on the spread of HIV among children. Focused research has yielded highly successful strategies for reducing infant infection rates, particularly in the developed world, and much work is underway to implement appropriate strategies in resource-limited settings, although this is not without challenges. Although transmission rates in some settings have been reduced to approximately 1%, scale-up and widespread implementation and application of strategic interventions for prevention of mother-to-child transmission of HIV during pregnancy, delivery and breastfeeding are needed in the developing world.

Mentioned in this Paper

Drug Resistance, Viral
Maternal-Fetal Infection Transmission
Pregnancy Complications, Infectious
Vertical Disease Transmission
HIV Infections
Breast Feeding
Anti-HIV Agents
Breast Feeding, Exclusive
HIV-1
Antiretroviral Therapy, Highly Active

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